1-(N-benzyloxycarbonyl-glycyloxy)-1H-benzotriazole | 26198-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(N-benzyloxycarbonyl-glycyloxy)-1H-benzotriazole
• 英文别名: Benzotriazol-1-yl 2-(phenylmethoxycarbonylamino)acetate
• CAS: 26198-39-0
• 化学式: C₁₆H₁₄N₄O₄
• 分子量: 326.312
• InChiKey: PDDPBGKZAIQUTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  95.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(N-benzyloxycarbonyl-glycyloxy)-1H-benzotriazole 在 ammonium hydroxide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 N-苄氧羰基甘氨酰胺
  参考文献：
  名称：

  Chen, Shui-Tein; Wu, Shih-Hsiung; Wang, Kung-Tsung, Synthesis, 1989, # 1, p. 37 - 38

  摘要：

  DOI：
• 作为产物：
  描述：

  1-羟基苯并三唑 、 N-苄氧羰基甘氨酸 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-(N-benzyloxycarbonyl-glycyloxy)-1H-benzotriazole
  参考文献：
  名称：

  Spirodiketopiperazines of mannofuranose: carbopeptoid α-amino acid esters at the anomeric position of mannofuranose

  摘要：

  Epimeric mannofuranose anomeric aminoesters are prepared from readily available azidolactones and can act as building blocks for the incorporation of mannofuranose units into peptide chains [carbopeptoids]; alternative acylating conditions allow either rapid acylation of the more stable but kinetically hindered amine or reaction with the less hindered but less stable amine to allow control of the anomeric configuration of the products. This is exemplified by coupling of the aminoesters with glycine derivatives to give dipeptide equivalents, and subsequent cyclization to spiro diketopiperazines, Anomers with the nitrogen function cis to the 2,3-diol are more stable than those with nitrogen trans; mannofuranose derivatives are more stable than the mannopyranose isomers. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00206-7

文献信息

• Beta-alanine derivatives and their use as receptor anatgonists
  申请人：——

  公开号：US20030018193A1

  公开（公告）日：2003-01-23

  A beta-alanine derivative of the formula (I) wherein R 1 is hydrogen atom or an amino protective group; A is a lower alkylene group or a lower alkenylene group; R 2 is hydrogen atom or an amino group which may be substituted with an acyl group; R 3 is hydrogen atom or an aryl or aralkyl group which may be substituted with one or more of hydroxy and/or lower alkoxy, a moiety represented by the formula (II), which is a bivalent N-containing 6- to 8-membered heterocyclic group, or a pharmaceutically acceptable salt thereof.

  公式（I）的β-丙氨酸衍生物，其中R1是氢原子或氨基保护基团；A是较低的烷基或较低的烯基基团；R2是氢原子或氨基团，可能被酰基取代；R3是氢原子或芳基或芳基基团，可能被一个或多个羟基和/或较低的烷氧基取代，由公式（II）表示的基团，该基团是一种双价的含氮6-到8-成员杂环基团，或其药用盐。
• BETA-ALANINE DERIVATIVES AND THEIR USE AS RECEPTOR ANTAGONISTS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1255748A1

  公开（公告）日：2002-11-13
• US6812235B2
  申请人：——

  公开号：US6812235B2

  公开（公告）日：2004-11-02
• [EN] BETA-ALANINE DERIVATIVES AND THEIR USE AS RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE BETA-ALANINE ET LEUR UTILISATION COMME ANTAGONISTES VIS-A-VIS D'UN RECEPTEUR
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2001060813A1

  公开（公告）日：2001-08-23

  A beta-alanine derivative of the formula (I) wherein R1 is hydrogen atom or an amino protective group; A is a lower alkylene group or a lower alkenylene group; R2 is hydrogen atom or an amino group which may be substituted with an acyl group; R3 is hydrogen atom or an aryl or aralkyl group which may be substituted with one or more of hydroxy and/or lower alkoxy, a moiety represented by the formula (II), which is a bivalent N-containing 6- to 8-membered heterocyclic group, or a pharmaceutically acceptable salt thereof.