2,2-Bis-<4-dimethylamino-phenyl>-1,3-dithiolan | 99949-85-6

• 分子结构分类: 有机化合物
• 英文名称: 2,2-Bis-<4-dimethylamino-phenyl>-1,3-dithiolan
• 英文别名: tetra-N-methyl-4,4'-[1,3]dithiolane-2,2-diyl-bis-aniline；2,2-bis-(4-dimethylaminophenyl)-1,3-dithiolane；4-[2-[4-(dimethylamino)phenyl]-1,3-dithiolan-2-yl]-N,N-dimethylaniline
• CAS: 99949-85-6
• 化学式: C₁₉H₂₄N₂S₂
• 分子量: 344.545
• InChiKey: ASDIBMKFECSVLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Temperature control system for cutaneous photodynamic therapy
  申请人：Spectra Systems Corporation

  公开号：US20030211138A1

  公开（公告）日：2003-11-13

  A method is disclosed for limiting temperature increase of a treatment area during photodynamic therapy (PDT), whereby temperature sensitive materials in the form of a skin patch or compound are applied over the treatment area. The temperature sensitive materials are optically changing from substantially transmissive to at least one of substantially scattering, absorbing or reflecting at wavelengths used for the PDT, the change occurring upon surpassing a predetermined temperature. In preferred embodiments, the optical changes are reversible as the temperature of the temperature sensitive compounds decrease below a predetermined temperature.

  本发明公开了一种在光动力疗法（PDT）过程中限制治疗区域温度升高的方法，即在治疗区域使用皮肤贴片或化合物形式的温度敏感材料。在光动力疗法使用的波长下，温度敏感材料的光学性能从基本透射变为基本散射、吸收或反射中的至少一种，这种变化在超过预定温度时发生。在优选的实施方案中，当温度敏感化合物的温度降低到预定温度以下时，光学变化是可逆的。
• [EN] TEMPERATURE CONTROL SYSTEM FOR CUTANEOUS PHOTODYNAMIC THERAPY<br/>[FR] SYSTEME DE REGULATION DE TEMPERATURE DESTINE AU TRAITEMENT PHOTODYNAMIQUE CUTANE
  申请人：SPECTRA SYSTEMS CORP

  公开号：WO2003070315A2

  公开（公告）日：2003-08-28

  A method is disclosed for limiting temperature increase of a treatment area during photodynamic therapy (PDT), whereby temperature sensitive materials in the form of a skin patch or compound are applied over the treatment area. The temperature sensitive materials are optically changing from substantially transmissive to at least one of substantially scattering, absorbing or reflecting at wavelengths used for the PDT, the change occurring upon surpassing a predetermined temperature. In preferred embodiments, the optical changes are reversible as the temperature of the temperature sensitive compounds decrease below a predetermined temperature.