6-(2-chloro-6-fluorophenyl)-8-cyclobutylmethyloxy-2-(4-morpholinophenyl)aminopyrido[2,3-d]pyrimidin-7-one | 1021304-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 6-(2-chloro-6-fluorophenyl)-8-cyclobutylmethyloxy-2-(4-morpholinophenyl)aminopyrido[2,3-d]pyrimidin-7-one
• 英文别名: 6-(2-Chloro-6-fluorophenyl)-8-(cyclobutylmethoxy)-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one
• CAS: 1021304-42-6
• 化学式: C₂₈H₂₇ClFN₅O₃
• 分子量: 536.005
• InChiKey: VQYFISPZORPSOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• PYRIDO [2,3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：Murthi Krisna

  公开号：US20110201594A1

  公开（公告）日：2011-08-18

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• US8518958B2
  申请人：——

  公开号：US8518958B2

  公开（公告）日：2013-08-27
• [EN] PYRIDO [2, 3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS<br/>[FR] PYRIDO[2,3-D]PYRIMIDINES ET UTILISATION DE CELLES-CI EN TANT QU'INHIBITEURS DE KINASES
  申请人：GPC BIOTECH INC

  公开号：WO2008047307A1

  公开（公告）日：2008-04-24

  [EN] The present invention provides derivatives of pyrido [2,3-d]pyrimidin-7-one of formula (I). These compounds are kinase inhibitors, including compounds that show antiproliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
  [FR] La présente invention concerne des dérivés de pyrido[2,3-d]pyrimidin-7-one de formule (I). Ces composés sont des inhibiteurs de kinases, comprenant des composés qui présentent une activité antiproliférative, y compris contre des cellules tumorales, et ils sont utiles dans le traitement de maladies dont le cancer.
• [EN] 8-OXY-2-AMINOPYRIDO (2, 3-D) PYRIMIDIN-7-ONE DERIVATIVES AS KINASE INHIBITORS AND ANTICANCER AGENTS<br/>[FR] INHIBITEURS DE KINASE
  申请人：GPC BIOTECH INC

  公开号：WO2008150260A1

  公开（公告）日：2008-12-11

  [EN] The present invention provides derivatives of pyrido [2, 3-d] pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
  [FR] La présente invention concerne des dérivés de pyrido[2,3-d]pyrimidin-7-one. Ces composés sont des inhibiteurs de kinase. Ils incluent des composés qui présentent une activité anti-proliférante, y compris contre les cellules tumorales, et se révèlent utiles dans le traitement de certaines maladies, du cancer entre autres.