(E)-4-(4-(二十六烷基氨基)苯乙烯基)-1-甲基吡啶鎓碘化物 | 114041-00-8

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (E)-4-(4-(二十六烷基氨基)苯乙烯基)-1-甲基吡啶鎓碘化物
• 中文别名: 4-[2-[4-(双十六烷基氨基)苯基]乙烯基]-1-甲基吡啶碘化物
• 英文名称: Diasp
• 英文别名: N,N-dihexadecyl-4-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]aniline;iodide
• CAS: 114041-00-8
• 化学式: C46H79IN2
• 分子量: 787.0
• InChiKey: YPGZWUVVEWKKDQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  11.45
• 重原子数：
  49
• 可旋转键数：
  33
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

制备方法与用途

用途

4-[2-[4-(双十六烷基氨基)苯基]乙烯基]-1-甲基吡啶碘化物可用作一种绿色荧光膜染料，可用作氨基苯乙烯基探针。

文献信息

• LYSOPHOSPHATIDIC ACID DETECTION
  申请人：PORTLAND STATE UNIVERSITY

  公开号：US20160047830A1

  公开（公告）日：2016-02-18

  Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.

  本发明揭示了一种用于分离和检测溶血磷脂酸（LPAs）的方法和化合物的实施例。还揭示了执行该方法的试剂盒。通过液液萃取后跟随固相萃取从生物样品中分离出LPAs。可以通过高效液相色谱分离LPA物种，并且可以鉴定和定量分离的物种。还揭示了一些化合物的实施例，这些化合物能够普遍检测多种LPAs物种，具有基本相等的灵敏度。所揭示的化合物的实施例对于在包含多种LPA物种的样品中测定总LPA浓度而无需分离单个LPA物种是有用的。
• KIT FOR DETECTING VIRUS
  申请人：Huvet Bio, Inc.

  公开号：EP3244210A1

  公开（公告）日：2017-11-15

  The present invention relates to a kit for detecting a virus, a composition for detecting a virus and a method for detecting a virus. According to the present invention, viruses may be detected with high efficiency at low cost within a short period of time.

  本发明涉及一种检测病毒的试剂盒、一种检测病毒的组合物和一种检测病毒的方法。根据本发明，可在短时间内以低成本高效率地检测病毒。
• Enhanced ultrasound detection with temperature-dependent contrast agents
  申请人：——

  公开号：US20020102216A1

  公开（公告）日：2002-08-01

  Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.

  本发明公开了根据温度变化和与超声目标结合的温度依赖性造影剂的超声反射率增强超声检测的方法和装置。这些方法和设备可单独用于增强成像，也可与给药、热疗或冷冻疗法等治疗方法或其他成像模式结合使用。
• Methods of detecting specific cell lysis
  申请人：——

  公开号：US20020146746A1

  公开（公告）日：2002-10-10

  The present invention provides methods of detecting specific lysis of a cell by a lytic agent. The methods generally involve contacting a labeled target cell with a lytic agent; and detecting fluorescence in the target cell. The target cells are labeled with two fluorescent labels: a first fluorescent label that labels the plasma membrane; and a second fluorescent label that labels the cytosol. Release of the cytosolic label from the target cell indicates that the target cell has been lysed. The invention further provides methods of detecting the presence in a sample of a cell that specifically lyses a target cell. The invention further provides methods of detecting the presence in a sample of an antibody that specifically lyses a target cell. The methods are useful in a variety of applications.

  本发明提供了检测细胞被溶解剂特异性溶解的方法。这些方法一般包括将标记的靶细胞与溶菌剂接触，并检测靶细胞中的荧光。靶细胞被两种荧光标签标记：第一种荧光标签标记质膜；第二种荧光标签标记细胞膜。从靶细胞中释放出细胞质标签表明靶细胞已被裂解。本发明进一步提供了检测样品中是否存在特异性裂解靶细胞的细胞的方法。本发明进一步提供了检测样品中是否存在特异性裂解靶细胞的抗体的方法。这些方法适用于多种应用。
• Beam-steering of multi-chromatic light using acousto-optical deflectors and dispersion-compensatory optics
  申请人：——

  公开号：US20020149769A1

  公开（公告）日：2002-10-17

  Method and apparatus for steering a beam of light. The method and apparatus are based on the discovery that the spectral dispersion of multi-chromatic light pulses by an acousto-optical deflector can be significantly ameliorated by positioning a dispersive element, such as a prism, along the path of the multi-chromatic light pulses in such a way that the dispersive element disperses the multi-chromatic light pulses in a direction opposite to the spectral dispersion caused by the acousto-optical deflector. The dispersive element may be positioned either before or after the acousto-optical deflector. The method and apparatus are particularly well-suited for use with ultrashort laser pulses in the visible and infrared ranges having a bandwidth of up to about 40 nm. The method and apparatus have applicability in, among other things, multi-photon laser scanning microscopy.

  转向光束的方法和装置。该方法和装置基于以下发现：通过沿多色光脉冲的路径定位分散元件（如棱镜），可以显著改善声光偏转器对多色光脉冲的光谱分散，分散元件分散多色光脉冲的方向与声光偏转器造成的光谱分散方向相反。色散元件可以设置在声光偏转器之前或之后。该方法和设备特别适合用于可见光和红外线范围内的超短激光脉冲，其带宽可达约 40 纳米。除其他外，该方法和装置还适用于多光子激光扫描显微镜。