4-Aminomethylbicyclo<2.2.2>oct-2-en-1-carbonsaeure | 24539-29-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Aminomethylbicyclo<2.2.2>oct-2-en-1-carbonsaeure
• 英文别名: 4-(aminomethyl)bicyclo[2.2.2]oct-2-ene-1-carboxylic acid
• CAS: 24539-29-5
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: ZLHZYQNFVKZWOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Antifibrinolytic compounds
  申请人：THROMBOLYTICS, LLC

  公开号：US10202331B2

  公开（公告）日：2019-02-12

  The present invention provides novel and antifibrinolytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding. The present application relates to numerous embodiments of chemical structures which in whole or in part mimic or are analogs of the amino acid Lysine such that they bind to specific binding site(s) within specific protein sub structures in the structures of Plasminogen, and/or Plasmin, and/or Plasminogen Activators, and/or Thrombin.

  本发明提供了新型抗纤维蛋白溶解化合物、其制备工艺、药物和兽药组合物及其在医学中的用途，特别是用于治疗出血。本申请涉及许多化学结构的实施方案，这些化学结构全部或部分模仿氨基酸赖氨酸或其类似物，从而使它们与特定蛋白质子结构中的特定结合位点结合，这些蛋白质子结构包括血浆蛋白酶原、和/或血浆蛋白、和/或血浆蛋白酶原激活剂、和/或凝血酶。
• ANTIFIBRINOLYTIC COMPOUNDS
  申请人：Thromboltyics, LLC

  公开号：EP3215145A2

  公开（公告）日：2017-09-13
• [EN] ANTIFIBRINOLYTIC COMPOUNDS<br/>[FR] COMPOSÉS ANTIFIBRINOLYTIQUES
  申请人：THROMBOLTYICS LLC

  公开号：WO2016073493A2

  公开（公告）日：2016-05-12

  The present invention provides novel antifibrinilytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding.