摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

2-methyl-2-((6-oxo-6-(2-thioxothiazolidin-3-yl)hexanoyloxy)methyl)propane-1,3-diyl bis(4-cyano-4-(ethylthiocarbonothioylthio)pentanoate) | 1217549-62-6

中文名称
——
中文别名
——
英文名称
2-methyl-2-((6-oxo-6-(2-thioxothiazolidin-3-yl)hexanoyloxy)methyl)propane-1,3-diyl bis(4-cyano-4-(ethylthiocarbonothioylthio)pentanoate)
英文别名
——
2-methyl-2-((6-oxo-6-(2-thioxothiazolidin-3-yl)hexanoyloxy)methyl)propane-1,3-diyl bis(4-cyano-4-(ethylthiocarbonothioylthio)pentanoate)化学式
CAS
1217549-62-6
化学式
C32H45N3O7S8
mdl
——
分子量
840.253
InChiKey
IGOPZCSHERKBTL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    7.71
  • 重原子数:
    50.0
  • 可旋转键数:
    21.0
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.72
  • 拓扑面积:
    146.79
  • 氢给体数:
    0.0
  • 氢受体数:
    17.0

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    描述:
    4-氰基-4-(((乙硫基)硫代羰基)硫基)戊酸3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 6-oxo-6(2-thioxothiazolidin-3-yl)hexanoate2-(dimethylamino)pyridinium p-toluenesulfonateN,N'-二环己基碳二亚胺 作用下, 以 二氯甲烷 为溶剂, 反应 16.0h, 以90%的产率得到2-methyl-2-((6-oxo-6-(2-thioxothiazolidin-3-yl)hexanoyloxy)methyl)propane-1,3-diyl bis(4-cyano-4-(ethylthiocarbonothioylthio)pentanoate)
    参考文献:
    名称:
    Synthesis, Characterization, and Bioactivity of Mid-Functional PolyHPMA−Lysozyme Bioconjugates
    摘要:
    A thiazolidine-2-thione mid-functionalized chain transfer agent (CTA) was synthesized and used as a reversible addition fragmentation chain transfer (RAFT) polymerization agent to prepare poly(N-(2-hydroxypropyl)methacrylamide) (polyHPMA) with mid-chain thiazolidine-2-thione functionality. The synthesized polymers were fully analyzed by H-1 NMR and GPC, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). A subsequent hydrolysis/analysis of the polymers was performed to verify their mid-functional structures. These mid-functionalized polymers were then incubated with a model protein (lysozyme) to generate branched polymer protein bioconjugates. The bioactivity of the branched polymer protein conjugate was tested and compared to similar molecular weight linear polyHPMA-protein bioconjugate; the branched polymer protein conjugate remained much more protein activity, indicating the mid-chain-functional polyHPMA was more selective in its conjugation reaction on the lysozyme surface when compared with conjugation reactions involving terminal-functional polyHPMA. This straightforward methodology, described herein, for the synthesis of branched polymer protein bioconjugates strikes a balance between protein protection by the attachment of polymer chains and the subsequent bioactivity retention of the bioconjugate.
    DOI:
    10.1021/ma100142w
点击查看最新优质反应信息