2,3,6,7,14,15-hexamethyl-9,10-diphosphatriptycene | 1187939-21-4

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 2,3,6,7,14,15-hexamethyl-9,10-diphosphatriptycene
• 英文别名: 4,5,11,12,17,18-Hexamethyl-1,8-diphosphapentacyclo[6.6.6.02,7.09,14.015,20]icosa-2(7),3,5,9(14),10,12,15(20),16,18-nonaene；4,5,11,12,17,18-hexamethyl-1,8-diphosphapentacyclo[6.6.6.02,7.09,14.015,20]icosa-2(7),3,5,9(14),10,12,15(20),16,18-nonaene
• CAS: 1187939-21-4
• 化学式: C₂₄H₂₄P₂
• 分子量: 374.402
• InChiKey: QWHKRTQTALSYIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  26
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,3,6,7,14,15-hexamethyl-9,10-diphosphatriptycene 在 水 、 溴 作用下， 以 氯仿 为溶剂， 反应 0.5h， 以100%的产率得到
  参考文献：
  名称：

  Bromine Adducts of 9,10-Diheteratriptycene Derivatives

  摘要：

  合成了2,3,6,7,14,15-六甲基-9,10-二磷酸三苯并庚烯（1）、2,3,6,7,14,15-六甲基-9-磷酸-10-锑酸三苯并庚烯（2）和2,3,6,7,14,15-六甲基-9,10-二锑酸三苯并庚烯（3），并通过X射线晶体学确定了它们的分子结构。2和3与溴反应，分别得到了组成为2·2Br2和3·2Br2的相应加合物8和9。加合物8和9均具有两性离子结构，由六配位锑酸阴离子(R3SbBr3−)和四配位磷阳离子/锑阳离子(R3MBr+: M = P或Sb)组成，处于晶体状态。加合物8的1H和31P NMR谱表明其在室温下的溶液中结构是静态的。而加合物9的1H NMR谱则暗示在27°C下发生快速异构化，但在-90°C时在NMR时间尺度上变慢。从THF–美克斯啉中重结晶加合物9，得到的晶体组成为3·2Br2·2THF，其中每个锑原子与两个溴原子和一个THF氧原子结合，形成八面体几何结构。

  DOI：

  10.1246/bcsj.82.819
• 作为产物：
  描述：

  tris(2-bromo-4,5-dimethylphenyl)phosphine 在 叔丁基锂 、 三氯化磷 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 以7%的产率得到2,3,6,7,14,15-hexamethyl-9,10-diphosphatriptycene
  参考文献：
  名称：

  观察带有含第 15 族元素的磷杂三萜骨架的非稳定鏻叶立德与苯甲醛的 Wittig 反应中间体

  摘要：

  摘要 已经研究了第 15 族元素（P、As、Sb 和 Bi）的杂原子效应对带有磷杂三苯甲醛骨架的非稳定鏻叶立德与苯甲醛的 Wittig 反应中立体化学漂移的影响。观察到 1,2-氧代膦烷作为中间体，并通过 VT-31P{1H} NMR 光谱在 -90°C 和 25°C 之间检测到从顺式到反式的异构化，这是立体化学漂移的起源。发现异构化在较低温度下开始，因为较重周期元素的原始数量。交叉实验表明，异构化是通过 1,2-氧杂膦烷和鏻叶立德-苯甲醛之间的平衡发生的。图形摘要

  DOI：

  10.1080/10426507.2018.1521410

文献信息

• Heteroatom effects toward isomerization of intermediates in Wittig reactions of non-stabilized phosphonium ylides bearing a phosphaheteratriptycene skeleton with benzaldehyde
  作者：Yosuke Uchiyama、Suguru Kuniya、Ryo Watanabe、Takemaru Ohtsuki

  DOI：10.1002/hc.21473

  日期：2018.12

  AbstractIsomerization of intermediates, cis‐ and trans‐1,2‐oxaphosphetanes, in Wittig reactions of non‐stabilized phosphonium ylides bearing a phosphaheteratriptycene skeleton containing group 14 (PhSi, PhGe, PhSn, n‐BuSn) and 15 (P, As, Sb, and Bi) elements with benzaldehyde (PhCHO) was investigated by variable‐temperature (VT)31P1H} NMR spectroscopy. The isomerization from the cis‐1,2‐oxaphosphetane to the trans‐form occurred at lower temperatures as the row number of the same group elements increases. Wittig reactions under the same conditions gave the (Z)‐olefin as a major product in the cases of period 3 elements (PhSi and P) and the (E)‐olefin as a major product in the cases of elements from period 4 and below (PhGe, PhSn, n‐BuSn, As, Sb, and Bi). The selectivity of olefin formation is considered to depend on the isomerization temperature of the intermediates, because each olefin must be obtained from the corresponding 1,2‐oxaphosphetane. The VT‐31P1H} NMR spectra showed that the cis‐1,2‐oxaphosphetanes were the kinetic products in the first step of Wittig reactions and the trans‐forms were the thermodynamically stable products formed by isomerization from the cis‐forms via ring‐opening and ring‐closing reactions of phosphonium ylides with PhCHO. Density functional theory (DFT) calculations indicated that cis‐1,2‐oxaphosphetanes were less stable than the trans‐forms by ~2 kcal/mol, supporting thermodynamically favorable isomerization from cis‐forms to trans‐forms, as observed by VT‐31P1H} NMR spectroscopy. Heteroatoms at the bridgehead position of the phosphaheteratriptycene skeleton significantly affected the isomerization temperature as well as the phosphorus‐31 signals in the 31P1H} NMR spectra, which were observed at lower field as row number of the same group element increases.
• Observation of intermediates in Wittig reactions of non-stabilized phosphonium ylides bearing a phosphaheteratriptycene skeleton containing Group 15 elements with benzaldehyde
  作者：Yosuke Uchiyama、Suguru Kuniya、Ryo Watanabe、Takemaru Ohtsuki

  DOI：10.1080/10426507.2018.1521410

  日期：2019.5.27

  heteroatom effect of Group 15 elements (P, As, Sb and Bi) has been investigated on stereochemical drift in the Wittig reactions of non-stabilized phosphonium ylides bearing a phosphaheteratriptycene skeleton with benzaldehyde. 1,2-Oxaphosphetanes were observed as intermediates and the isomerization from cis-form to trans-form, the origin of stereochemical drift, was detected between −90 °C and 25 °C by VT-31P1H}

  摘要 已经研究了第 15 族元素（P、As、Sb 和 Bi）的杂原子效应对带有磷杂三苯甲醛骨架的非稳定鏻叶立德与苯甲醛的 Wittig 反应中立体化学漂移的影响。观察到 1,2-氧代膦烷作为中间体，并通过 VT-31P1H} NMR 光谱在 -90°C 和 25°C 之间检测到从顺式到反式的异构化，这是立体化学漂移的起源。发现异构化在较低温度下开始，因为较重周期元素的原始数量。交叉实验表明，异构化是通过 1,2-氧杂膦烷和鏻叶立德-苯甲醛之间的平衡发生的。图形摘要
• Bromine Adducts of 9,10-Diheteratriptycene Derivatives
  作者：Yosuke Uchiyama、Jun Sugimoto、Munenori Shibata、Gaku Yamamoto、Yasuhiro Mazaki

  DOI：10.1246/bcsj.82.819

  日期：2009.7.15

  2,3,6,7,14,15-Hexamethyl-9,10-diphosphatriptycene (1), 2,3,6,7,14,15-hexamethyl-9-phospha-10-stibatriptycene (2), and 2,3,6,7,14,15-hexamethyl-9,10-distibatriptycene (3) were synthesized and their molecular structures were determined by X-ray crystallography. Reactions of 2 and 3 with bromine gave the corresponding adducts 8 and 9 with the compositions 2·2Br2 and 3·2Br2, respectively. Both of the adducts 8 and 9 have a zwitterionic structure composed of a hexacoordinate stiborate anion, (R3SbBr3−) and a tetracoordinate phosphonium/stibonium cation (R3MBr+: M = P or Sb) in the crystalline state. 1H and 31P NMR spectra of the adduct 8 indicated that the structure is static in solution at room temperature. On the other hand, 1H NMR spectra of the adduct 9 suggested fast topomerization at 27 °C, which becomes slow on the NMR time scale at −90 °C. Recrystallization of the adduct 9 from THF–mesitylene gave crystals with the composition of 3·2Br2·2THF, in which each antimony atom bonds to two bromine atoms and one THF oxygen to give an octahedral geometry.

  合成了2,3,6,7,14,15-六甲基-9,10-二磷酸三苯并庚烯（1）、2,3,6,7,14,15-六甲基-9-磷酸-10-锑酸三苯并庚烯（2）和2,3,6,7,14,15-六甲基-9,10-二锑酸三苯并庚烯（3），并通过X射线晶体学确定了它们的分子结构。2和3与溴反应，分别得到了组成为2·2Br2和3·2Br2的相应加合物8和9。加合物8和9均具有两性离子结构，由六配位锑酸阴离子(R3SbBr3−)和四配位磷阳离子/锑阳离子(R3MBr+: M = P或Sb)组成，处于晶体状态。加合物8的1H和31P NMR谱表明其在室温下的溶液中结构是静态的。而加合物9的1H NMR谱则暗示在27°C下发生快速异构化，但在-90°C时在NMR时间尺度上变慢。从THF–美克斯啉中重结晶加合物9，得到的晶体组成为3·2Br2·2THF，其中每个锑原子与两个溴原子和一个THF氧原子结合，形成八面体几何结构。