4-(chloromethyl)-6-(cyclohexylmethoxy)spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane] | 1192852-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4-(chloromethyl)-6-(cyclohexylmethoxy)spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]
• CAS: 1192852-01-9
• 化学式: C₂₀H₂₇ClO₃
• 分子量: 350.886
• InChiKey: CQTGQWFJFDSYDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.82
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(chloromethyl)-6-(cyclohexylmethoxy)spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane] 、 1H-1,2,3-三唑并[4,5-b]吡啶 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 以80.4 mg的产率得到3-((5-(cyclohexylmethoxy)spiro[benzo[d][1,3]dioxole-2,1'-cyclohexan]-7-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridine
  参考文献：
  名称：

  A new structural class of S-adenosylhomocysteine hydrolase inhibitors

  摘要：

  Effective inhibitors of S-adenosylhomocysteine hydrolase hold promise towards becoming useful therapeutic agents. Since most efforts have focused on the development of nucleoside analog inhibitors, issues regarding bioavailability and selectivity have been major challenges. Considering the marine sponge metabolite ilimaquinone was found to be a competitive inhibitor of S-adenosylhomocysteine hydrolase, new opportunities for developing selective new inhibitors of this enzyme have become available. Based on the activities of various hybrid analogs, SAR studies, pharmacophore modeling, and computer docking studies have lead to a predictive understanding of ilimaquinone's S-adenosylhomocysteine hydrolase inhibitory activities. These studies have allowed for the design and preparation of simplified structural variants possessing new furanoside bioisosteres with 100-fold greater inhibitory activities than that of the natural product. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2009.07.061
• 作为产物：
  描述：

  在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以82%的产率得到4-(chloromethyl)-6-(cyclohexylmethoxy)spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]
  参考文献：
  名称：

  A new structural class of S-adenosylhomocysteine hydrolase inhibitors

  摘要：

  Effective inhibitors of S-adenosylhomocysteine hydrolase hold promise towards becoming useful therapeutic agents. Since most efforts have focused on the development of nucleoside analog inhibitors, issues regarding bioavailability and selectivity have been major challenges. Considering the marine sponge metabolite ilimaquinone was found to be a competitive inhibitor of S-adenosylhomocysteine hydrolase, new opportunities for developing selective new inhibitors of this enzyme have become available. Based on the activities of various hybrid analogs, SAR studies, pharmacophore modeling, and computer docking studies have lead to a predictive understanding of ilimaquinone's S-adenosylhomocysteine hydrolase inhibitory activities. These studies have allowed for the design and preparation of simplified structural variants possessing new furanoside bioisosteres with 100-fold greater inhibitory activities than that of the natural product. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2009.07.061