ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-({[(1-methyl-1H-imidazol-2-yl)methyl]thio}methyl)nicotinate | 1039036-84-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-({[(1-methyl-1H-imidazol-2-yl)methyl]thio}methyl)nicotinate
• 英文别名: Ethyl 6-[4-(benzylsulfonylcarbamoyl)piperidin-1-yl]-5-cyano-2-[(1-methylimidazol-2-yl)methylsulfanylmethyl]pyridine-3-carboxylate
• CAS: 1039036-84-4
• 化学式: C₂₈H₃₂N₆O₅S₂
• 分子量: 596.731
• InChiKey: JLHOUMTXVWRRHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  181
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• New Pyridine Analogues VIII 518
  申请人：Antonsson Thomas

  公开号：US20080200448A1

  公开（公告）日：2008-08-21

  The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

  本发明涉及某些新的Formula(I)吡啶类似物、制备这些化合物的方法、它们作为P2Y12抑制剂和抗血栓药物等的用途、它们作为心血管疾病药物的使用，以及包含它们的制药组合物。
• [EN] NEW PYRIDINE ANALOGUES VIII 518<br/>[FR] NOUVEAUX ANALOGUES DE LA PYRIDINE VIII 518
  申请人：ASTRAZENECA AB

  公开号：WO2008085119A1

  公开（公告）日：2008-07-17

  [EN] The present invention relates to certain new pyridin analogues of Formula ( I ) to processes for preparing such compounds, to their utility as P2Y₁₂ inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
  [FR] La présente invention concerne certains nouveaux analogues de la pyridine de formule (I), des procédés de préparation de tels composés, leur utilisation en tant qu'inhibiteurs de P2Y₁₂ et en tant qu'agents anti-thrombotiques, etc., leur utilisation en tant que médicaments dans des maladies cardiovasculaires ainsi que des compositions pharmaceutiques qui les contiennent.