2-chloro-β-alanine ethyl ester; hydrochloride | 61685-20-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-chloro-β-alanine ethyl ester; hydrochloride
• 英文别名: 2-Chlor-β-alanin-aethylester; Hydrochlorid；Ethyl 3-amino-2-chloropropanoate--hydrogen chloride (1/1)；ethyl 3-amino-2-chloropropanoate;hydrochloride
• CAS: 61685-20-9
• 化学式: C₅H₁₀ClNO₂*ClH
• 分子量: 188.054
• InChiKey: HKRZTXMFJABEOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.54
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-Chlor-3-amino-propionsaeure 、 乙醇 在 盐酸 作用下， 生成 2-chloro-β-alanine ethyl ester; hydrochloride
  参考文献：
  名称：

  Gundermann; Holtmann, Chemische Berichte, 1958, vol. 91, p. 160,166

  摘要：

  DOI：

文献信息

• Process for producing solutions of aziridine-2-carboxylic acid salts
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0030475A1

  公开（公告）日：1981-06-17

  A process for producing aziridine-2-carboxylic acid or its salts is provided which comprises treating an alpha-halogeno-beta-aminopropionitrile or its mineral acid salt with an alkali or alkaline earth metal hydroxide in water or in a water-containing organic solvent. In a preferred embodiment, aziridine-2-carboxylic acid or its salt is produced by treating the reaction mixture containing an alpha-halogeno-beta-aminopropionitrile obtained by reacting an alpha, beta-dihalogenopropionitrile or an alpha-halogenoacrylonitrile with ammonia, with an alkali or alkaline earth metal hydroxide in the presence of water without isolating the alpha-halogeno-beta-aminopropionitrile from the reaction mixture beforehand.

  本发明提供了一种生产氮丙啶-2-羧酸或其盐的工艺，包括在水中或含水有机溶剂中用碱或碱土金属氢氧化物处理α-卤代-beta-氨基丙腈或其矿物酸盐。在一个优选的实施方案中，氮丙啶-2-羧酸或其盐的制备方法是：将含有由α，β-二卤代丙腈或α-卤代丙烯腈与氨反应得到的α-卤代-β-氨基丙腈的反应混合物与碱或碱土金属氢氧化物在有水的情况下进行处理，而不事先将α-卤代-β-氨基丙腈从反应混合物中分离出来。
• Process for producing solutions of aziridine-2-carboxylic acid salt
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0030870A1

  公开（公告）日：1981-06-24

  A process for producing an aziridine-2-carboxylic acid salt is provided which comprises treating an alpha-halogeno-beta-aminopropionic acid, its ester or a mineral acid salt of said acid or ester with an alkali metal hydroxide, an alkaline earth metal hydroxide or aqueous ammonia in water or a water-containing organic solvent.

  提供了一种生产氮丙啶-2-羧酸盐的工艺，该工艺包括在水中或含水有机溶剂中用碱金属氢氧化物、碱土金属氢氧化物或氨水处理α-卤代-beta-氨基丙酸、其酯或所述酸或酯的矿物酸盐。
• Purification of aziridine-2-carboxylic acid salts
  申请人：RESEARCH ASSOCIATION FOR UTILIZATION OF LIGHT OIL

  公开号：EP0191462A1

  公开（公告）日：1986-08-20

  Alkaline earth metal salts of aziridine-2-carboxylic acid, typically Ca salt, are produced by a reaction of a 2,3-diha- iopropionic acid derivative or an a-haloacrylic acid derivative with an aqueous ammonia in the presence of an alkaline earth metal hydroxide, typically Ca(OH)2. Salts of aziridine-2-carboxylic acid are recovered from such a reaction product as referred to above by a liquid chromatographic technique in which a weak or weakened cation exchanger is utilized.

  氮丙啶-2-羧酸的碱土金属盐，通常为 Ca 盐，是由 2,3-二哈-碘丙酸衍生物或 a-卤丙烯酸衍生物与水氨在碱土金属氢氧化物（通常为 Ca(OH)2）存在下反应生成的。
• US4393000A
  申请人：——

  公开号：US4393000A

  公开（公告）日：1983-07-12
• US4935527A
  申请人：——

  公开号：US4935527A

  公开（公告）日：1990-06-19