6-(1-amino-2-methylpropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one | 876191-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(1-amino-2-methylpropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one
• 英文别名: 6-(1-amino-2-methyl-propyl)-5-(3-fluoro-benzyl)-3-methyl-5H-isothiazolo[5,4-d]pyrimidin-4-one；6-(1-Amino-2-methylpropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[5,4-d]pyrimidin-4-one
• CAS: 876191-33-2
• 化学式: C₁₇H₁₉FN₄OS
• 分子量: 346.428
• InChiKey: NUIAFZZBXLGHLI-UHFFFAOYSA-N

物化性质

• 沸点：
  452.2±55.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  99.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-(1-amino-2-methylpropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 67.0h， 生成 tert-butyl N-[3-[[1-[5-[(3-fluorophenyl)methyl]-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl]-2-methylpropyl]-(4-methylbenzoyl)amino]propyl]carbamate
  参考文献：
  名称：

  Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent

  摘要：

  Structure activity relationship analysis identified (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting both excellent biochemical potency and pharmaceutical properties suitable for clinical development. The selected compound arrested cells in mitosis leading to the formation of the monopolar spindle phenotype characteristic of KSP inhibition and induction of cellular death. A favorable pharmacokinetic profile and notable in vivo efficacy supported the selection of this compound as a clinical candidate for the treatment of cancer.

  DOI：

  10.1021/jm200629m
• 作为产物：
  描述：

  6-(1-azido-2-methylpropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one 在 5%-palladium/activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 生成 6-(1-amino-2-methylpropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-[1,2]thiazolo[4,5-e]pyrimidin-4-one
  参考文献：
  名称：

  Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent

  摘要：

  Structure activity relationship analysis identified (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting both excellent biochemical potency and pharmaceutical properties suitable for clinical development. The selected compound arrested cells in mitosis leading to the formation of the monopolar spindle phenotype characteristic of KSP inhibition and induction of cellular death. A favorable pharmacokinetic profile and notable in vivo efficacy supported the selection of this compound as a clinical candidate for the treatment of cancer.

  DOI：

  10.1021/jm200629m

文献信息

• SELECTED FUSED HETEROCYCLICS AND USES THEREOF
  申请人：AstraZeneca AB

  公开号：EP1781673B1

  公开（公告）日：2009-10-21