(Z)-7-[(1R,2R,3R)-2-((E)-4-benzo[b]thiophen-3-yl-3-hydroxy-but-1-enyl)-3-hydroxy-6-oxo-cyclohexyl]-hept-5-enoic acid | 845791-57-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-7-[(1R,2R,3R)-2-((E)-4-benzo[b]thiophen-3-yl-3-hydroxy-but-1-enyl)-3-hydroxy-6-oxo-cyclohexyl]-hept-5-enoic acid
• 英文别名: (Z)-7-[(1R,2R,3R)-2-[(E)-4-(1-benzothiophen-3-yl)-3-hydroxybut-1-enyl]-3-hydroxy-6-oxocyclohexyl]hept-5-enoic acid
• CAS: 845791-57-3
• 化学式: C₂₅H₃₀O₅S
• 分子量: 442.576
• InChiKey: GACJXSNXHABDRY-UCJXOOEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Cyclohexyl prostaglandin analogs as EP4-receptor agonists
  申请人：Old W. David

  公开号：US20050049227A1

  公开（公告）日：2005-03-03

  The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP 4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I: wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R 1 , R 2 and R 3 are as defined in the specification.

  本发明涉及使用新型环己基E型前列腺素类似物作为EP4激动剂，通常作为眼压降低剂。本发明中使用的环己基类似物由以下公式I表示：其中波浪线代表α或β键，虚线代表键W的存在或不存在，Y，Z，R，R1，R2和R3如规范中所定义。
• Cyclohexyl prostaglandin analogs as rp4-receptor agonists
  申请人：Old W. David

  公开号：US20060247215A1

  公开（公告）日：2006-11-02

  The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP 4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I: wherein the wavy segments represent α or β bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R 1 , R 2 and R 3 are as defined in the specification.
• US7015243B2
  申请人：——

  公开号：US7015243B2

  公开（公告）日：2006-03-21
• US7429615B2
  申请人：——

  公开号：US7429615B2

  公开（公告）日：2008-09-30
• US7473704B2
  申请人：——

  公开号：US7473704B2

  公开（公告）日：2009-01-06