米多霉素 | 67527-71-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 米多霉素
• 英文名称: 4-Amino-1-[4-[[(2S)-2-amino-3-hydroxy-1-oxopropyl]amino]-9-[(aminoiminomethyl)amino]-6-C-carboxy-2,3,4,7,9-pentadeoxy-|A-L-talo-non-2-enopyranosyl]-5-(hydroxymethyl)-2(1H)-pyrimidinone
• 英文别名: 2-[6-[4-amino-5-(hydroxymethyl)-2-oxopyrimidin-1-yl]-3-[(2-amino-3-hydroxypropanoyl)amino]-3,6-dihydro-2H-pyran-2-yl]-5-(diaminomethylideneamino)-2,4-dihydroxypentanoic acid
• CAS: 67527-71-3
• 化学式: C₁₉H₃₀N₈O₉
• 分子量: 514.5
• InChiKey: QKJJCZYFXJCKRX-UHFFFAOYSA-N

物化性质

• 熔点：
  >300° (monohydrate)
• 比旋光度：
  D20 +100° (c = 0.5 in water); +78.5° (c = 0.5 in 0.1N HCl)
• 密度：
  1.81±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -8.1
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  306
• 氢给体数：
  10
• 氢受体数：
  11

制备方法与用途

Mildiomycin 是一种由轮状链霉菌（Streptoverticillum rimofaciens）产生的抗大麦白粉病抗生素。它能够抑制某些分枝杆菌和红酵母的生长，但对于多数真菌和细菌则无效。

文献信息

• N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：US20140315898A1

  公开（公告）日：2014-10-23

  The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , n have the meanings given in the description—to their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation

  本发明涉及公式（I）中的新型N-芳酰胺取代三氟乙基硫醚衍生物，其中X1、X2、X3、X4、R1、R2、R3、n的含义如描述所示—它们作为杀螨剂和杀虫剂用于控制动物害虫，并涉及其制备的过程和中间体。
• ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20160145235A1

  公开（公告）日：2016-05-26

  The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulphide and aryl sulphoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.

  本发明涉及芳基硫醚和芳基亚砜衍生物，其用作杀螨剂和杀虫剂，用于控制动物害虫，并涉及其制备的过程和中间体。芳基硫醚和芳基亚砜衍生物具有一般结构（I），其中各自的基团如描述中所定义。
• [EN] FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'HYDROXYMOYL-TÉTRAZOLE FONGICIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2012123434A1

  公开（公告）日：2012-09-20

  The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions, wherein A represents a tetrazoyi group, Het represents a pyridyl group or a thiazolyl group and X represents various substituents.

  本发明涉及式(I)的羟肟基-四唑衍生物，其制备方法，它们作为杀真菌活性剂的用途，特别是作为杀真菌组合物的形式以及利用这些化合物或组合物控制植物病原真菌的方法，其中A代表四唑基，Het代表吡啶基或噻唑基，X代表各种取代基。
• [EN] N-[(HET)ARYLALKYL)] PYRAZOLE (THIO)CARBOXAMIDES AND THEIR HETEROSUBSTITUTED ANALOGUES<br/>[FR] N-[(HET)ARYLALKYL)]PYRAZOLE(THIO)CARBOXAMIDES ET LEURS ANALOGUES HÉTÉROSUBSTITUÉS
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2011151370A1

  公开（公告）日：2011-12-08

  The present invention relates to fungicidal N-[(het)arylalkyl)] pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogues, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.

  本发明涉及杀真菌N-[(het)arylalkyl)]吡唑甲酰胺或硫代甲酰胺及其杂原子取代的类似物，它们的制备方法和制备中间体化合物，它们作为杀菌剂的用途，特别是作为杀菌剂组合物的形式和利用这些化合物或它们的组合物控制植物病原真菌的方法。
• [EN] 1-(HETEROCYCLIC CARBONYL) PIPERIDINES<br/>[FR] 1-(CARBONYL HÉTÉROCYCLIQUE)PIPÉRIDINES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2012052489A1

  公开（公告）日：2012-04-26

  The present invention relates to fungicidal 1-(heterocyclic carbonyl) piperidines and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.

  本发明涉及杀真菌剂1-(杂环羰基)哌啶和其硫代羰基衍生物，其制备方法和制备中间体，它们作为杀真菌剂的用途，特别是作为杀真菌剂组合物的形式，以及使用这些化合物或它们的组合物控制植物的植物病原真菌的方法。