trifluoro-acetic acid 3-ethyl-5-(1-ethyl-propoxy)-6'-isopropyl-6-methylamino-[2,3']bipyridinyl-2'-yl ester | 477598-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: trifluoro-acetic acid 3-ethyl-5-(1-ethyl-propoxy)-6'-isopropyl-6-methylamino-[2,3']bipyridinyl-2'-yl ester
• 英文别名: [3-[3-Ethyl-6-(methylamino)-5-pentan-3-yloxypyridin-2-yl]-6-propan-2-ylpyridin-2-yl] 2,2,2-trifluoroacetate
• CAS: 477598-29-1
• 化学式: C₂₃H₃₀F₃N₃O₃
• 分子量: 453.505
• InChiKey: VWJUPJQJKIXGPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  73.3
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 5-Substituted-2-arylpyridines
  申请人：Neurogen Corporation

  公开号：US20030152520A1

  公开（公告）日：2003-08-14

  Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供了一种新型的5-取代-2-芳基吡啶化合物。这种化合物可以作为CRF受体的选择性调节剂。本文提供的5-取代-2-芳基吡啶化合物在治疗许多中枢神经系统和外周疾病方面具有用途，特别是在应对压力、焦虑、抑郁、心血管疾病和饮食障碍方面。还提供了治疗这些疾病的方法以及包装的药物组合物。提供的化合物还可用作CRF受体定位的探针和CRF受体结合测定中的标准。还给出了使用这些化合物进行受体定位研究的方法。
• 5-Substituted-2-Arylpyridines
  申请人：Ge Ping

  公开号：US20080107608A1

  公开（公告）日：2008-05-08

  Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRP receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  本发明提供了一种新型的5-取代-2-芳基吡啶化合物。这些化合物可以作为选择性调节CRP受体的调节剂。本发明提供的5-取代-2-芳基吡啶化合物在治疗许多中枢神经系统和周围疾病方面具有用途，特别是在应对压力、焦虑、抑郁、心血管疾病和进食障碍方面。本发明还提供了治疗这些疾病的方法以及配制的药物组合物。提供的化合物还可用作CRF受体定位的探针，以及CRF受体结合测定中的标准物质。给出了使用这些化合物进行受体定位研究的方法。
• US7223778B2
  申请人：——

  公开号：US7223778B2

  公开（公告）日：2007-05-29