Furan-2-yl-propynoyl chloride | 131292-18-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: Furan-2-yl-propynoyl chloride
• 英文别名: 3-(Furan-2-yl)prop-2-ynoyl chloride
• CAS: 131292-18-7
• 化学式: C₇H₃ClO₂
• 分子量: 154.553
• InChiKey: HCZZJCGCSZEDGK-UHFFFAOYSA-N

物化性质

• 沸点：
  227.9±32.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Furan-2-yl-propynoyl chloride 在 三乙胺 作用下， 以 甲苯 为溶剂， 25.0~500.0 ℃ 、13.33 Pa 条件下， 反应 4.0h， 生成 ethyl 5-(2-furyl)penta-2,4-diynoate
  参考文献：
  名称：

  Flash vacuum pyrolysis of stabilised phosphorus ylides. Part 4. Stepwise construction of terminal 1, 3-diynes, conjugated diacetylenic esters and a triacetylenic ester

  摘要：

  Thirteen examples of stabilised alkynoyl ylides 6 have been prepared and are found, upon flash vacuum pyrolysis (FVP) at 500 degrees C, to undergo extrusion of Ph(3)PO to give the diacetylenic esters 7 in moderate yield. At 750 degrees C the same ylides afforded terminal 1.3-diynes 8 although often in poor yield. For R = 2-MeSC(6)H(4) both 7 and 8 undergo secondary loss of Me(.) and cyclisation to give 2-alkynylbenzothiophene derivatives 9 and 10 in low yield. The first example of an alkadiynoyl ylide 11 has been prepared and is converted by FVP at 500 degrees C into the triacetylenic ester 12.

  DOI：

  10.1039/p19940002461
• 作为产物：
  描述：

  ethyl (2-furyl)propiolate 在 sodium hydroxide 、 氯化亚砜 、 苄基三乙基氯化铵 作用下， 以 乙醚 、 水 为溶剂， 反应 126.0h， 生成 Furan-2-yl-propynoyl chloride
  参考文献：
  名称：

  Flash vacuum pyrolysis of stabilised phosphorus ylides. Part 4. Stepwise construction of terminal 1, 3-diynes, conjugated diacetylenic esters and a triacetylenic ester

  摘要：

  Thirteen examples of stabilised alkynoyl ylides 6 have been prepared and are found, upon flash vacuum pyrolysis (FVP) at 500 degrees C, to undergo extrusion of Ph(3)PO to give the diacetylenic esters 7 in moderate yield. At 750 degrees C the same ylides afforded terminal 1.3-diynes 8 although often in poor yield. For R = 2-MeSC(6)H(4) both 7 and 8 undergo secondary loss of Me(.) and cyclisation to give 2-alkynylbenzothiophene derivatives 9 and 10 in low yield. The first example of an alkadiynoyl ylide 11 has been prepared and is converted by FVP at 500 degrees C into the triacetylenic ester 12.

  DOI：

  10.1039/p19940002461

文献信息

• AITKEN, R. ALAN;SETH, SHIRLEV, SYNLETT.,(1990) N, C. 212-213
  作者：AITKEN, R. ALAN、SETH, SHIRLEV

  DOI：——

  日期：——
• AITKEN, R. ALAN;SETH, SHIRLEY, SYNLETT,(1990) N, C. 211-212
  作者：AITKEN, R. ALAN、SETH, SHIRLEY

  DOI：——

  日期：——
• Aitken R. Alan, Seth Shirley, J. Chem. Soc. Perkin Trans., (1994) N 17, S 2461-2466
  作者：Aitken R. Alan, Seth Shirley

  DOI：——

  日期：——