(trans)-1-hydroxy-4-{[N-(2,2-dimethoxy-ethyl)-N-methyl-amino]-carbonylmethylamino}-cyclohexane | 1046452-56-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (trans)-1-hydroxy-4-{[N-(2,2-dimethoxy-ethyl)-N-methyl-amino]-carbonylmethylamino}-cyclohexane
• 英文别名: N-(2,2-dimethoxyethyl)-2-[(4-hydroxycyclohexyl)amino]-N-methylacetamide
• CAS: 1046452-56-5
• 化学式: C₁₃H₂₆N₂O₄
• 分子量: 274.36
• InChiKey: UZAMYGWISZZQHG-UHFFFAOYSA-N

物化性质

• 沸点：
  414.3±45.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  71
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• BICYCLIC HETEROCYCLES, DRUGS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION THEREOF
  申请人：Himmelsbach Frank

  公开号：US20100022505A1

  公开（公告）日：2010-01-28

  The present invention relates to bicyclic heterocycles of general formula wherein R a , R b and R c are defined as in claim 1 , their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids and bases, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.

  本发明涉及一般式的双环杂环化合物 其中 R a ，R b 和R c 如权利要求中所定义， 它们的互变异构体，立体异构体，混合物和盐，特别是它们与无机或有机酸和碱形成的生理上可接受的盐，具有有价值的药理特性，特别是对酪氨酸激酶介导的信号传导具有抑制作用，它们用于治疗疾病，特别是肿瘤性疾病和良性前列腺增生（BPH），肺部和气道疾病，以及其制备。
• PROCESS FOR THE STEREOSELECTIVE PREPARATION OF BICYCLIC HETEROCYCLES
  申请人：Ostermeier Markus

  公开号：US20120116080A1

  公开（公告）日：2012-05-10

  The present invention relates to a process for the stereoselective preparation of compounds of general formula (I) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.

  本发明涉及一种立体选择性合成通式(I)化合物及其盐的方法，尤其是与无机或有机酸和碱形成的生理学上可接受的盐，这些化合物具有有价值的药理学性质，特别是对酪氨酸激酶介导的信号传导具有抑制作用，可用于治疗疾病，特别是肿瘤性疾病以及良性前列腺增生症、肺和气道疾病。
• US7998949B2
  申请人：——

  公开号：US7998949B2

  公开（公告）日：2011-08-16
• US8263768B2
  申请人：——

  公开号：US8263768B2

  公开（公告）日：2012-09-11