Octahydro-3.6-aetheno-benzocyclobutan-1.2.4.5-tetracarbonsaeure | 5698-86-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Octahydro-3.6-aetheno-benzocyclobutan-1.2.4.5-tetracarbonsaeure
• 英文别名: Tricyclo[4.2.2.0(2,5)]dec-9-ene-3,4,7,8-tetracarboxylic acid；tricyclo[4.2.2.02,5]dec-9-ene-3,4,7,8-tetracarboxylic acid
• CAS: 5698-86-2
• 化学式: C₁₄H₁₄O₈
• 分子量: 310.26
• InChiKey: WQTLHUWYZRQEJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• SELF-ASSEMBLY OF THERAPEUTIC AGENT-PEPTIDE NANOSTRUCTURES
  申请人：Ohio State Innovation Foundation

  公开号：US20140155577A1

  公开（公告）日：2014-06-05

  Disclosed are conjugates of hydrophobic drugs linked to protected or unprotected amino acids or peptides. The disclosed conjugates are amphiphilic and can self assemble into nanotubes. Nanotubes comprising the conjugates are also described and can have high loading of the drug and protect it from degradation or elimination. The nanotubes are well suited to deliver hydrophobic and unstable drugs to individuals.

  揭示了与受保护或未受保护的氨基酸或肽连接的疏水药物的共轭物。所述的共轭物是两性的，可以自组装成纳米管。还描述了包含这些共轭物的纳米管，可以具有高药物载荷并保护药物免受降解或排泄。这些纳米管非常适合向个体输送疏水和不稳定的药物。
• POLYIMIDE PRECURSOR, POLYIMIDE, AND MATERIALS TO BE USED IN PRODUCING SAME
  申请人：Takasawa Ryoichi

  公开号：US20130178597A1

  公开（公告）日：2013-07-11

  Disclosed is a novel co-polyimide precursor for producing a polyimide having high transparency. The co-polyimide precursor comprises a unit structure represented by general Formula (A1) and a unit structure represented by general Formula (A2): wherein, in general Formula (A1), R 1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and R 2 and R 3 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkylsilyl group having 3 to 9 carbon atoms, wherein, in general Formula (A2), R 4 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 5 and R 6 each independently represent a hydrogen, an alkyl group having 1 to 6 carbon atoms, or an alkylsilyl group having 3 to 9 carbon atoms; and X represents a tetravalent group other than those represented by Formulae (A3):

  本发明涉及一种新型共聚酰亚胺前体，用于制备具有高透明度的聚酰亚胺。该共聚酰亚胺前体包括由通式（A1）表示的单元结构和由通式（A2）表示的单元结构：其中，在通式（A1）中，R1表示氢原子或具有1至4个碳原子的烷基基团；R2和R3各自独立地表示氢原子、具有1至6个碳原子的烷基基团或具有3至9个碳原子的烷基硅基团，在通式（A2）中，R4表示氢原子或具有1至4个碳原子的烷基基团；R5和R6各自独立地表示氢原子、具有1至6个碳原子的烷基基团或具有3至9个碳原子的烷基硅基团；X表示除通式（A3）所表示的四价基团以外的四价基团。
• LACTIC ACID POLYMER COMPOSITION AND MOLDED OBJECT THEREOF
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP1454958A1

  公开（公告）日：2004-09-08

  Disclosed herein are a lactic acid-based polymer composition comprising: (i) an amide compound represented by General Formula (1): wherein R1 represents a C2-30 saturated or unsaturated aliphatic polycarboxylic acid residue, a C4-28 saturated or unsaturated alicyclic polycarboxylic acid residue, or a C6-28 aromatic polycarboxylic acid residue, and R2 represents C1-18 alkyl, C2-18 alkenyl, C3-12 cycloalkyl or cycloalkenyl or the like, (ii) an ester plasticizer, and (iii) a lactic acid-based polymer; a transparent, crystalline (heat resistant) molded article molded from such a lactic acid-based polymer composition; and a method for producing such a molded article.

  本文公开了一种乳酸基聚合物组合物，该组合物包含：(i) 通式(1)代表的酰胺化合物： 其中 R1 代表 C2-30 饱和或不饱和脂肪族多羧酸残基、C4-28 饱和或不饱和脂环族多羧酸残基或 C6-28 芳香族多羧酸残基，R2 代表 C1-18 烷基、C2-18 烯基、C3-12 环烷基或环烯基或类似物，(ii) 酯增塑剂，以及 (iii) 乳酸基聚合物；用这种乳酸基聚合物组合物模制的透明结晶（耐热）模制件；以及生产这种模制件的方法。
• RESIN-ADDITIVE MASTERBATCH
  申请人：Adeka Corporation

  公开号：EP2578620A1

  公开（公告）日：2013-04-10

  The present invention provides a resin additive masterbatch which not only is capable of containing a resin additive having a low melting point at a high concentration, but also can be continuously produced without strand breakage and has an improved surface tackiness. The resin additive masterbatch comprises, with respect to 100 parts by mass of (A) a crystalline resin, 100 to 900 parts by mass of (B) a resin additive, 0.1 to 10 parts by mass of (C) a metal salt of an organic acid other than fatty acid and 0.1 to 10 parts by mass of (D) a gelling agent, the resin additive masterbatch being characterized in that the above-described (B) resin additive retains a liquid state when melted with heating to 250°C and then cooled to 80°C and kept for 30 minutes.

  本发明提供了一种树脂添加剂母料，它不仅能在高浓度下含有低熔点的树脂添加剂， 而且能连续生产而不会断股，并具有更好的表面粘性。 该树脂添加剂母料包括（A）结晶树脂 100 至 900 份（按重量计）、（B）树脂添加剂 100 至 900 份（按重量计）、（C）脂肪酸以外的有机酸金属盐 0.1 至 10 份（按重量计）和（D）胶凝剂 0.1 至 10 份（按重量计）、 该树脂添加剂母料的特点是，上述（B）树脂添加剂在加热熔化至 250℃，然后冷却至 80℃并保持 30 分钟后，仍保持液态。
• Self-assembly of therapeutic agent-peptide nanostructures
  申请人：Ohio State Innovation Foundation

  公开号：US10098967B2

  公开（公告）日：2018-10-16

  Disclosed are conjugates of hydrophobic drugs linked to protected or unprotected amino acids or peptides. The disclosed conjugates are amphiphilic and can self assemble into nantubes. Nanotubes comprising the conjugates are also described and can have high loading of the drug and protect it from degradation or elimination. The nanotubes are well suited to deliver hydrophobic and unstable drugs to individuals.

  所公开的是疏水性药物与受保护或未受保护的氨基酸或肽连接的共轭物。所公开的共轭物具有两亲性，可自行组装成纳米管。此外，还描述了包含共轭物的纳米管，这种纳米管可具有较高的药物负载量，并能保护药物不被降解或消除。纳米管非常适合向人体输送疏水性和不稳定的药物。