N-{2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]ethyl}-4-pyridin-4-ylbutan-1-amine | 666850-15-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-{2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]ethyl}-4-pyridin-4-ylbutan-1-amine
• 英文别名: 1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-[5-(3,5-dimethylphenyl)-4-[2-(4-pyridin-4-ylbutylamino)ethyl]-6H-thieno[2,3-b]pyrrol-2-yl]-2-methylpropan-1-one
• CAS: 666850-15-3
• 化学式: C₃₅H₄₄N₄OS
• 分子量: 568.827
• InChiKey: IEJRJPZZJGTCTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  89.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 6H-thieno'2, 3-b!pyrrole derivatives as antagonists of gonadotropin releasing hormone (gnrh)
  申请人：Foote Michael Kevin

  公开号：US20060004082A1

  公开（公告）日：2006-01-05

  The invention relates to a group of novel thieno-pyrrole compounds of Formula (1): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

  本发明涉及一组新型噻吩-吡咯化合物，化学式为（1）：其中：R1、R2、R3、R4和R5如规范中所定义，它们可用作促性腺激素释放激素拮抗剂。本发明还涉及所述化合物的制药配方、使用所述化合物的治疗方法以及所述化合物的制备方法。
• 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
  申请人：Foote Michael Kevin

  公开号：US20060235067A1

  公开（公告）日：2006-10-19

  The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

  本发明涉及一组新型噻吩-吡咯化合物，化学式为（I）：其中：R1、R2、R3、R4和R5如规范中所定义，它们可用作促性腺激素释放激素拮抗剂。本发明还涉及所述化合物的制药配方、使用所述化合物的治疗方法以及制备所述化合物的方法。
• 6H-THIEN 2, 3-B]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
  申请人：AstraZeneca AB

  公开号：EP1543012B1

  公开（公告）日：2008-07-16
• US7132442B2
  申请人：——

  公开号：US7132442B2

  公开（公告）日：2006-11-07
• US7268158B2
  申请人：——

  公开号：US7268158B2

  公开（公告）日：2007-09-11