2-Cyclohexylpropan-1,1-dicarbonsaeure | 28811-74-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Cyclohexylpropan-1,1-dicarbonsaeure
• 英文别名: 2-(1-Cyclohexylethyl)propanedioic acid
• CAS: 28811-74-7
• 化学式: C₁₁H₁₈O₄
• 分子量: 214.262
• InChiKey: LVYDEOSZIIYOJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF<br/>[FR] ADDITIONS DE CONJUGUÉS AVEC DÉCARBOXYLATION ET APPLICATIONS ASSOCIÉES
  申请人：UNIV PRINCETON

  公开号：WO2016196931A1

  公开（公告）日：2016-12-08

  Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.

  本文描述了可操作的合成方法，能够通过脱羧机制通过共轭加成有效地产生各种分子物种。例如，描述了肽残基的官能化方法，包括对肽C-末端残基的选择性官能化。在一个方面，肽官能化方法包括提供包括迈克尔受体和肽的反应混合物，并通过包括肽残基的脱羧机制将迈克尔受体与肽偶联。
• Decarboxylative conjugate additions and applications thereof
  申请人：The Trustees of Princeton University

  公开号：US11136349B2

  公开（公告）日：2021-10-05

  Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.

  本文介绍的合成方法可通过脱羧机制进行共轭添加，从而有效地生产多种分子物质。例如，描述了肽残基官能化的方法，包括肽 C 端残基的选择性官能化。在一个方面，肽官能化的方法包括提供包括迈克尔受体和肽的反应混合物，并通过包括肽残基脱羧的机制将迈克尔受体与肽偶联。
• ANTI-VIRAL COMPOUNDS
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0565631A1

  公开（公告）日：1993-10-20
• DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF
  申请人：The Trustees of Princeton University

  公开号：US20180179248A1

  公开（公告）日：2018-06-28

  Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.
• US5559140A
  申请人：——

  公开号：US5559140A

  公开（公告）日：1996-09-24