(E)-3-(3,4-dihydroxybenzylidene)-7-propoxychroman-4-one | 1454901-95-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 英文名称: (E)-3-(3,4-dihydroxybenzylidene)-7-propoxychroman-4-one
• 英文别名: (3E)-3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-propoxy-4H-1-benzopyran-4-one；(3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-propoxychromen-4-one
• CAS: 1454901-95-1
• 化学式: C₁₉H₁₈O₅
• 分子量: 326.349
• InChiKey: PTAPEAOFPYLSSE-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-propoxychroman-4-one 、 3,4-二羟基苯甲醛 在 盐酸 、 溶剂黄146 作用下， 反应 24.0h， 以67%的产率得到(E)-3-(3,4-dihydroxybenzylidene)-7-propoxychroman-4-one
  参考文献：
  名称：

  Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones

  摘要：

  A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1, 1 -diphenyl-2-picrylhydrazy] (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.034

文献信息

• Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones
  作者：Alireza Foroumadi、Alireza Samzadeh-Kermani、Saeed Emami、Gholamreza Dehghan、Maedeh Sorkhi、Fatemeh Arabsorkhi、Mahmoud Reza Heidari、Mohammad Abdollahi、Abbas Shafiee

  DOI：10.1016/j.bmcl.2007.10.034

  日期：2007.12

  A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1, 1 -diphenyl-2-picrylhydrazy] (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox. (c) 2007 Elsevier Ltd. All rights reserved.