Chatterjee, Amareshwar; Dutta, Lakshmi N.; Chatterjee, Swapan K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 11, p. 955 - 960
Chatterjee, Amareshwar; Dutta, Lakshmi N.; Chatterjee, Swapan K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 11, p. 955 - 960
Tributyltin hydride-mediated radical cyclisation of aldehydes and unsaturated ketones: the synthesis of hydroxy tetrahydrofurans, chromanols and related compounds
作者:David Bebbington、Jon Bentley、Paul A Nilsson、Andrew F Parsons
DOI:10.1016/s0040-4039(00)01586-0
日期:2000.11
The tributyltin hydride-mediated cyclisation of unsaturated ethers bearing an aldehyde or α,β-unsaturated ketone group is reported. Cyclisation proceeds viaaddition of the tributyltin radical to the carbonyl double bond and the resultant O-stannyl ketyl can add intramolecularly to electron-rich double bonds to form hydroxy tetrahydrofurans, chromanols or related compounds.
Tributyltin hydride-mediated radical cyclisation of carbonyls to form functionalised oxygen and nitrogen heterocycles
作者:Jon Bentley、Paul A. Nilsson、Andrew F. Parsons
DOI:10.1039/b202077g
日期:2002.6.7
The tributyltin hydride-mediated cyclisation of unsaturated ethers and aminesbearing an aldehyde or α,β-unsaturated ketone group is reported. Cyclisation proceeds via reversible addition of the tributyltin radical to the carbonyl double bond to form an intermediate O-stannyl ketyl. This nucleophilic radical can add intramolecularly to electron-rich double bonds to form substituted 5- or 6-membered
Reductions par les hydrures et hydroboration etude de la stereoselectivite de nouvelles voies d'acces aux 3-arylmethyl-4-chromanols (Homoisoflavanols)
作者:Michel Gomis、B. Serge Kirkiacharian
DOI:10.1016/s0040-4020(01)89754-4
日期:1990.1
The reduction of 3-arylmethyl-4-chromanones by sodium borohydride, lithium tri-tert-butoxyaluminum hydride and hydroboration followed by oxydation of 3-benzyl-4-hydroxy-coumarines lead to mixtures of Cis and Trans diastereoisomers of 3-arylmethyl-4-chromanols (homoisoflavanols). The reduction of 3-arylmethyl-4-chroma- nones by diborane or bis-tert-butylthioethane diborane (BTED) is stereoselective
Gomis, M.; Kirkiacharian, B.S.; Likforman, J., Bulletin de la Societe Chimique de France, 1988, # 3, p. 585 - 590
作者:Gomis, M.、Kirkiacharian, B.S.、Likforman, J.、Mahuteau, J.
DOI:——
日期:——
Synthesis and antirhinovirus activity of new 3-benzyl chromene and chroman derivatives
作者:Cinzia Conti、Nicoletta Desideri
DOI:10.1016/j.bmc.2009.03.051
日期:2009.5
A series of 3-benzyl chromenes and chromans were synthesized and tested in vitro against human rhinovirus (HRV) 1B and 14, two representative serotypes for rhinovirus group B and A, respectively. All the new compounds, with the exception of 3-benzyl-2H-chromene (3a), showed a potent activity against HRV serotype 1B within micro or submicromolar range (IC(50)s from 0.11 to 6.62 mu M). The low cytotoxicity of all the derivatives resulted in compounds with high therapeutic index (TI). On the contrary, HRV 14 infection was only weakly inhibited by the majority of these compounds. The 3-benzylidenechromans 2b and 2c showed the highest anti-HRV 1B activity (IC50 0.12 and 0.11 mu M, respectively) coupled with remarkable TI (625.00 and 340.91, respectively). Mechanism of action studies on (Z)-3-(4-chlorobenzylidene) chroman (2b) suggest that the new compounds behave as capsid binders and interfere with very early stages of HRV 1B replication, similarly to related flavanoids. (C) 2009 Elsevier Ltd. All rights reserved.