9H-占吨-1-羧酸,5-乙酰基-7-[(5-羧基-6,7-二羟基-4-羰基-2H-1-苯并吡喃-3(4H)-亚基)羟甲基]-2,3-二羟基-6-甲基-9-羰基- | 151466-15-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 中文名称: 9H-占吨-1-羧酸,5-乙酰基-7-[(5-羧基-6,7-二羟基-4-羰基-2H-1-苯并吡喃-3(4H)-亚基)羟甲基]-2,3-二羟基-6-甲基-9-羰基-
• 英文名称: Xanthofulvin
• 英文别名: 5-acetyl-7-[(Z)-(5-carboxy-6,7-dihydroxy-4-oxochromen-3-ylidene)-hydroxymethyl]-2,3-dihydroxy-6-methyl-9-oxoxanthene-1-carboxylic acid
• CAS: 151466-15-8
• 化学式: C₂₈H₁₈O₁₄
• 分子量: 578.4
• InChiKey: VZJACTNXARYXEM-NHDPSOOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  42
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  245
• 氢给体数：
  7
• 氢受体数：
  14

文献信息

• Novel Imaging Agents for Cancer
  申请人：Kindberg Grete Mork

  公开号：US20080279771A1

  公开（公告）日：2008-11-13

  A novel imaging agent is described which comprises a semaphorin moiety and an imaging moiety. The novel imaging agent of the invention may be used in the diagnostic imaging of cancer and in particular, for targeting angiogenesis or metaplasia. Further aspects of the present invention presented herein include a method for the preparation of the imaging agent, a pharmaceutical composition comprising the imaging agent of the invention and a kit for the preparation of said pharmaceutical.

  本发明提供了一种新型成像试剂，其包括一个semaphorin基团和一个成像基团。该发明的新型成像试剂可用于癌症的诊断成像，特别是针对血管生成或异型增生的定位。本发明的进一步方面包括制备成像试剂的方法，包含该成像试剂的药物组合物以及用于制备该药物组合物的试剂盒。
• Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
  申请人：Kimura Toru

  公开号：US20070015820A1

  公开（公告）日：2007-01-18

  To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
• Therapeutic or preventive agents for ischemic neuropathy
  申请人：Ikeda Kazuhito

  公开号：US20070105948A1

  公开（公告）日：2007-05-10

  Therapeutic or preventive agents for ischemic nerve injury containing as the active ingredient compounds represented by the general formula [2]: wherein R 1 and R 4 are each independently hydrogen, carboxy, or alkoxycarbonyl; and R 2 and R 5 are each independently hydrogen, hydroxy group, or acyloxy group.
• US7244761B2
  申请人：——

  公开号：US7244761B2

  公开（公告）日：2007-07-17
• US7317038B2
  申请人：——

  公开号：US7317038B2

  公开（公告）日：2008-01-08