7-propoxychroman-4-one | 1000817-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-propoxychroman-4-one
• CAS: 1000817-00-4
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: JEYVPDGITVVTHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  7-propoxychroman-4-one 、 3,4-二羟基苯甲醛 在 盐酸 、 溶剂黄146 作用下， 反应 24.0h， 以67%的产率得到(E)-3-(3,4-dihydroxybenzylidene)-7-propoxychroman-4-one
  参考文献：
  名称：

  Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones

  摘要：

  A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1, 1 -diphenyl-2-picrylhydrazy] (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.034
• 作为产物：
  描述：

  7-羟基色满-4-酮 、 1-碘代丙烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以81%的产率得到7-propoxychroman-4-one
  参考文献：
  名称：

  Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones

  摘要：

  A series of 3-benzylidene-7-alkoxychroman-4-one derivatives were synthesized and evaluated for their antioxidant activities. The antioxidant activity was assessed using three methods, namely, 1, 1 -diphenyl-2-picrylhydrazy] (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and thiobarbituric acid reactive substances (TBARS) assays. 3-Benzylidene-7-alkoxychroman-4-one derivatives bearing catecholic group on benzylidene moiety exhibited excellent antioxidant activity. Compounds having catechol moiety exhibited potent antioxidant activities in all tested methods and they were more active than the reference drug, Trolox. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.034