1-[(3S,4R)-3-([1,1′-联苯基]-4-基甲基）-3,4-二氢-4-羟基-2H-1-苯并吡喃-7-基]-环戊烷羧酸 | 158081-99-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 中文名称: 1-[(3S,4R)-3-([1,1′-联苯基]-4-基甲基）-3,4-二氢-4-羟基-2H-1-苯并吡喃-7-基]-环戊烷羧酸
• 中文别名: (+)-1-(3S,4R)-[3-（4-苯基苄基）-4-羟基色烷-7-基]环戊烷羧酸
• 英文名称: 1-(3-(4-Phenylbenzyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
• 英文别名: 1-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]cyclopentane-1-carboxylic acid
• CAS: 158081-99-3
• 化学式: C₂₈H₂₈O₄
• 分子量: 428.5
• InChiKey: KMNLXCBYBKHKSK-BKMJKUGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
  申请人：Sandanayaka Vincent

  公开号：US20070066820A1

  公开（公告）日：2007-03-22

  The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

  这项发明涉及一种化学类别的双芳基取代杂环抑制剂，用于治疗、预防和预防炎症性疾病和紊乱。这些化合物具有一般公式Ψ：一个例子是
• Novel Methods for Bone Treatment by Modulating an Arachidonic Acid Metabolic or Signaling Pathway
  申请人：O'Connor James Patrick

  公开号：US20110105959A1

  公开（公告）日：2011-05-05

  Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods rely on in vivo or ex vivo modulation of an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5-lipoxygenase inhibitors, leukotriene A4 hydrolase inhibitors, and/or leukotriene B4 receptor antagonists. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.

  公开了促进成骨作用以加速或增强骨折愈合、治疗骨缺陷和增强骨形成的方法。这些方法依赖于体内或体外调节花生四烯酸代谢或信号通路的总体，特别是利用5-脂氧合酶抑制剂、白三烯A4水解酶抑制剂和/或白三烯B4受体拮抗剂。这些分子可以单独或与一个或多个抑制骨吸收、调节从骨中钙吸收、增强骨积累、增强骨形成、诱导骨形成、抑制微生物生长、减少炎症和/或减轻疼痛的剂量联合使用。
• Preventive or therapeutic agent for age-related macular degeneration
  申请人：JUNTENDO EDUCATIONAL FOUNDATION

  公开号：US10849954B2

  公开（公告）日：2020-12-01

  To provide a new preventive or therapeutic agent for age-related macular degeneration. The present invention relates to a preventive or therapeutic agent for age-related macular degeneration containing a BLT1 antagonist or a LTB4 biosynthesis inhibitor as an active ingredient. The administration form of the preventive or therapeutic agent for age-related macular degeneration of the present invention includes eye drops, injections, oral agents (tablets, granules, dispersions, capsules), ointments, and creams. The form of these pharmaceutical compositions can be formulated by combining with a pharmaceutically acceptable carrier.

  为老年性黄斑变性提供一种新的预防或治疗剂。 本发明涉及一种老年性黄斑变性的预防或治疗剂，其活性成分含有 BLT1 拮抗剂或 LTB4 生物合成抑制剂。本发明的老年性黄斑变性预防剂或治疗剂的给药形式包括滴眼剂、注射剂、口服剂（片剂、颗粒剂、分散剂、胶囊剂）、软膏和霜剂。这些药物组合物的形式可以通过与药学上可接受的载体结合来配制。
• PREVENTIVE OR THERAPEUTIC AGENT FOR AGE-RELATED MACULAR DEGENERATION
  申请人：JUNTENDO EDUCATIONAL FOUNDATION

  公开号：US20170333516A1

  公开（公告）日：2017-11-23

  To provide a new preventive or therapeutic agent for age-related macular degeneration. The present invention relates to a preventive or therapeutic agent for age-related macular degeneration containing a BLT1 antagonist or a LTB 4 biosynthesis inhibitor as an active ingredient. The administration form of the preventive or therapeutic agent for age-related macular degeneration of the present invention includes eye drops, injections, oral agents (tablets, granules, dispersions, capsules), ointments, and creams. The form of these pharmaceutical compositions can be formulated by combining with a pharmaceutically acceptable carrier.
• US7402684B2
  申请人：——

  公开号：US7402684B2

  公开（公告）日：2008-07-22