4-phenoxymethyl-[1,3]dioxolane | 67775-77-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-phenoxymethyl-[1,3]dioxolane
• 英文别名: 4-Phenoxymethyl-[1,3]dioxolan；4-(Phenoxymethyl)-1,3-dioxolane
• CAS: 67775-77-3
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: BWAJZUJBUXHRPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 3-苯氧基-1,2-丙二醇 在 硫酸 作用下， 生成 4-phenoxymethyl-[1,3]dioxolane
  参考文献：
  名称：

  Read; Lathrop; Chandler, Journal of the American Chemical Society, 1927, vol. 49, p. 3117

  摘要：

  DOI：

文献信息

• [EN] NOVEL FUNCTIONALIZED 4-(PHENOXYMETHYL(-1,3-DIOXOLANE ANALOGS EXHIBITING CYTOCHROME P450 INHIBITION AND THEIR METHOD OF USE<br/>[FR] NOUVEAUX ANALOGUES 4-(PHÉNOXYMÉTHYL)-1,3-DIOXOLANE FONCTIONNALISÉS PRÉSENTANT UNE INHIBITION DU CYTOCHROME P450 ET LEUR PROCÉDÉ D'UTILISATION
  申请人：CORTENDO AB PUBL

  公开号：WO2014122530A1

  公开（公告）日：2014-08-14

  Embodiments of the present invention relate to 4-(phenoxymethyl)-1,3-dioxolane analogs and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the overproduction of Cortisol that include metabolic syndrome, and any involving the overproduction of Cortisol.

  本发明实施例涉及4-(苯氧甲基)-1,3-二噁烷类似物及其药物组合物，在治疗与皮质醇过度产生相关的疾病方面具有疾病修饰作用，包括代谢综合征以及任何涉及皮质醇过度产生的疾病。
• NOVEL FUNCTIONALIZED 4-(PHENOXYMETHYL(-1,3-DIOXOLANE ANALOGS EXHIBITING CYTOCHROME P450 INHIBITION AND THEIR METHOD OF USE
  申请人：CORTENDO AB (PUBL)

  公开号：US20150353530A1

  公开（公告）日：2015-12-10

  Embodiments of the present invention relate to 4-(phenoxymethyl)-1,3-dioxolane analogs and pharmaceutical compositions thereof having a disease-modifying action in the treatment of diseases associated with the overproduction of cortisol that include metabolic syndrome, and any involving the overproduction of cortisol.

  本发明实施例涉及4-(苯氧甲基)-1,3-二氧杂环己烷类似物及其制药组合物，具有治疗与皮质醇过度产生相关的疾病的疾病改善作用，包括代谢综合征和任何涉及皮质醇过度产生的疾病。
• PROCESS FOR PRODUCING POLYOXYMETHYLENE COPOLYMER
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP1876193A1

  公开（公告）日：2008-01-09

  The problem to be solved is to provide a process for producing a polyoxymethylene copolymer in a molding machine with a reduced generation of formaldehyde gas. In a process for continuously producing a polyoxymethylene copolymer comprising a step of melt-kneading a crude polyoxymethylene copolymer at a temperature not lower than the melting point thereof, devolatilizing under reduced pressure the formaldehyde gas generated as a decomposition product, subsequently mixing a formaldehyde scavenger containing a hydrazide compound (A) while keeping the copolymer in a molten state and immediately pelletizing the mixture, a dispersed solution obtained by slurry-dispersing said (A) in a diluent (B) having a melting point lower than temperature (Ta) which is the lower of the melting point and the decomposition temperature of (A), within a temperature range not lower than the melting point of (B) and lower than (Ta) is used as the formaldehyde scavenger.

  要解决的问题是提供一种在成型机中生产聚甲醛共聚物的工艺，该工艺可减少甲醛气体的产生。在一种连续生产聚甲醛共聚物的工艺中，包括以下步骤：在不低于熔点的温度下对粗聚甲醛共聚物进行熔融捏合，在减压下使作为分解产物产生的甲醛气体脱溶，随后在保持共聚物处于熔融状态的同时混合含有酰肼化合物（A）的甲醛清除剂，并立即对混合物进行造粒、将所述 (A) 在稀释剂 (B) 中进行浆状分散而得到的分散溶液用作甲醛清除剂，稀释剂 (B) 的熔点低于 (A) 的熔点和分解温度中较低的温度 (Ta)，温度范围不低于 (B) 的熔点且低于 (Ta)。
• PROCESS FOR PRODUCTION OF OXYMETHYLENE COPOLYMERS
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2050774A1

  公开（公告）日：2009-04-22

  The present invention relates to a process for producing an oxymethylene copolymer comprising the step of continuously polymerizing trioxane (as a component A) with a cyclic ether and/or a cyclic formal (as a component B) having a ring structure containing at least one carbon-to-carbon bond in a polymerization reaction system in the presence of a cationic polymerization catalyst, wherein a glycidyl compound and/or an alcohol (as a component C) is intermittently fed to a polymerization raw material or the polymerization reaction system containing at least one of the components A and B at latest until an initial stage of the polymerization reaction under the following conditions (1), (2) and (3): (1) A ratio of a feed time (t) for intermittently feeding the component C to a feed time (T) for feeding the component A to the polymerization reaction system is from 1/600 to 1/6; (2) an amount of the component C fed over the feed time (t) is from 0.4 to 50 mmol per 1 mol of the component A; and (3) a whole amount of the component C fed is from 0.0004 to 0.5 mmol per 1 mol of the component A.

  本发明涉及一种生产氧亚甲基共聚物的工艺，该工艺包括以下步骤：在阳离子聚合催化剂存在下，在聚合反应体系中连续聚合三氧杂环己烷（作为组分A）与环状醚和/或环状醛（作为组分B），环状醚和/或环状醛具有至少含有一个碳-碳键的环状结构、 其中缩水甘油化合物和/或醇（作为组分 C）在以下条件（1）、（2）和（3）下间歇地加入到聚合原料或含有至少一种组分 A 和 B 的聚合反应体系中，最迟至聚合反应的初始阶段： (1) 间歇向聚合反应体系加入组分 C 的进料时间 (t) 与加入组分 A 的进料时间 (T) 之比为 1/600 至 1/6； (2) 在进料时间（t）内进料的 C 组分的量为每 1 摩尔 A 组分 0.4 至 50 毫摩尔；以及 (3) 每 1 摩尔 A 组分 C 的全量为 0.0004 至 0.5 毫摩尔。
• LOW-FISHEYE POLYACETAL RESIN
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2305725A1

  公开（公告）日：2011-04-06

  The present invention provides a polyacetal resin which has excellent spinnability and excellent moldability with little optical unevenness when it is molded into a film or a sheet. The present invention provides a polyacetal resin in which the number of fisheyes having a maximum length of 30 µm or longer is 100 or less per 25 cm2 when it is measured using a film having a thickness of 30 µm.

  本发明提供了一种聚缩醛树脂，当它被模塑成薄膜或片材时，具有极佳的可纺性和极佳的可模塑性，几乎没有光学不均匀性。本发明提供了一种聚缩醛树脂，在使用厚度为 30 微米的薄膜进行测量时，其最大长度为 30 微米或更长的鱼眼数量为每 25 平方厘米 100 个或更少。