diosgenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-4-O-triethylsilyl-α-L-arabinopyranoside | 321125-18-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: diosgenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-4-O-triethylsilyl-α-L-arabinopyranoside
• CAS: 321125-18-2
• 化学式: C₆₅H₁₀₈O₁₄Si₃
• 分子量: 1197.82
• InChiKey: OKHHXQUNGNIPMA-IBYGJGCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.17
• 重原子数：
  82.0
• 可旋转键数：
  23.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  144.9
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  diosgenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-4-O-triethylsilyl-α-L-arabinopyranoside 以 水 、 溶剂黄146 为溶剂， 反应 3.0h， 以97%的产率得到diosgenin-3-yl 2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl-(1->3)-2-O-acetyl-α-L-arabinopyranoside
  参考文献：
  名称：

  Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1→4-linked analogue and their antitumor activities

  摘要：

  Twelve glycosides bearing the disaccharide of OSW-1, namely 2-O-(4-methoxybenzoyl)-beta -D-xylopyranosyl-(1 --> 3)-2-O-acetyl-alpha -L-arabinopyranosides, or its 1 --> 4-linked analogue, were synthesized, and their antitumor activities were determined. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(00)00225-1
• 作为产物：
  描述：

  phenyl 3,4-O-isopropylidene-1-thio-α-L-arabinopyranoside 在 咪唑 、 4-二甲氨基吡啶 、 N-碘代丁二酰亚胺 、 4 Angstroem MS 、 silver trifluoromethanesulfonate 作用下， 以 吡啶 、 二氯甲烷 、 水 、 溶剂黄146 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 3.0h， 生成 diosgenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-4-O-triethylsilyl-α-L-arabinopyranoside
  参考文献：
  名称：

  Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1→4-linked analogue and their antitumor activities

  摘要：

  Twelve glycosides bearing the disaccharide of OSW-1, namely 2-O-(4-methoxybenzoyl)-beta -D-xylopyranosyl-(1 --> 3)-2-O-acetyl-alpha -L-arabinopyranosides, or its 1 --> 4-linked analogue, were synthesized, and their antitumor activities were determined. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(00)00225-1