8-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one | 677708-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one
• 英文别名: 8-[2-[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-4,4-dimethyl-1,3-dihydroquinolin-2-one
• CAS: 677708-93-9
• 化学式: C₂₄H₂₇ClN₄OS
• 分子量: 455.024
• InChiKey: CZQLNSNIKYXQHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one 在 硼烷 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline
  参考文献：
  名称：

  8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity

  摘要：

  Several new, potent dopamine subtype 2 (DA D-2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.097
• 作为产物：
  描述：

  3-氯苯乙酸 在 镍 硝酸铵 、 三氯化铝 、 dimethyl sulfide borane 、 氢气 、 双(2-氧代-3-恶唑烷基)次磷酰氯 、 三乙胺 、 三氟乙酸酐 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 、 氯苯 、 甲苯 为溶剂， 生成 8-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one
  参考文献：
  名称：

  8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity

  摘要：

  Several new, potent dopamine subtype 2 (DA D-2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.097

文献信息

• Heterocyclic substituted piperazines for the treatment of schizophrenia
  申请人：——

  公开号：US20040067960A1

  公开（公告）日：2004-04-08

  This invention relates to compounds of the formula 1 1 wherein Ar, A, R 2 , R 3 , Y and ring Q are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.

  这项发明涉及到式11中的化合物，其中Ar、A、R2、R3、Y和环Q的定义如规范中所述，含有它们的药物组合物以及它们在治疗中枢神经系统疾病中的用途。
• HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA
  申请人：WARNER-LAMBERT COMPANY LLC

  公开号：EP1546145A1

  公开（公告）日：2005-06-29
• [EN] HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA<br/>[FR] PIPERAZINES SUBSTITUEES HETEROCYCLIQUES DESTINEES AU TRAITEMENT DE LA SCHIZOPHRENIE
  申请人：WARNER LAMBERT CO

  公开号：WO2004029048A1

  公开（公告）日：2004-04-08

  This invention relates to compounds of the formula 1 wherein Ar, A, R2, R3, Y and ring Q are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
• 8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity
  作者：Jamie M. Singer、Bridget M. Barr、Linda L. Coughenour、Tracy F. Gregory、Michael A. Walters

  DOI：10.1016/j.bmcl.2005.06.097

  日期：2005.10

  Several new, potent dopamine subtype 2 (DA D-2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia. (c) 2005 Elsevier Ltd. All rights reserved.