[2-benzyloxy-1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-isopropyl-amine | 1057215-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [2-benzyloxy-1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-isopropyl-amine
• 英文别名: N-[(1R)-1-(5-phenyl-1H-imidazol-2-yl)-2-phenylmethoxyethyl]propan-2-amine
• CAS: 1057215-39-0
• 化学式: C₂₁H₂₅N₃O
• 分子量: 335.449
• InChiKey: NBMAPUDTPKSJHB-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  49.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS
  申请人：Breslin J. Henry

  公开号：US20080096888A1

  公开（公告）日：2008-04-24

  The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

  本发明涉及式(I)的新型阿片受体调节剂。本发明还涉及制备这些化合物的方法、含有它们的药物组合物以及它们在治疗可能通过调节阿片受体改善或治疗的疾病中的应用。
• PROCESS FOR THE PREPARATION OF OPIOD MODULATORS
  申请人：Cai Chaozhong

  公开号：US20100036132A1

  公开（公告）日：2010-02-11

  The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.

  本发明涉及制备阿片类调节剂（激动剂和拮抗剂）及其合成中间体的新型工艺。这些阿片类调节剂可用于治疗和预防疼痛和胃肠道疾病。
• PROCESS FOR THE PREPARATION OF OPIOID MODULATORS
  申请人：Cai Chaozhong

  公开号：US20100152460A1

  公开（公告）日：2010-06-17

  The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.

  本发明涉及一种新型工艺，用于制备阿片类调节剂（激动剂和拮抗剂）及其合成中间体。这些阿片类调节剂可用于治疗和预防疼痛和胃肠障碍。
• US20140256779A1
  申请人：——

  公开号：US20140256779A1

  公开（公告）日：2014-09-11
• US7629488B2
  申请人：——

  公开号：US7629488B2

  公开（公告）日：2009-12-08