(S)-N-(8-(2-amino-4-methylpentyloxy)-7-(difluoromethyl)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide | 1454913-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (S)-N-(8-(2-amino-4-methylpentyloxy)-7-(difluoromethyl)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide
• 英文别名: N-[8-[(2S)-2-amino-4-methylpentoxy]-7-(difluoromethyl)-5H-chromeno[3,4-c]pyridin-2-yl]acetamide
• CAS: 1454913-26-8
• 化学式: C₂₁H₂₅F₂N₃O₃
• 分子量: 405.445
• InChiKey: WMPNVFZZTAXJDZ-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  86.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] ARYL ETHER-BASE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES DE TYPE ARYLÉTHER-BASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015038112A1

  公开（公告）日：2015-03-19

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开涉及一般可抑制AAK1（适配器相关激酶1）的化合物，包括这些化合物的组合物，以及抑制AAK1的方法。
• Aryl Ether-Base Kinase Inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20130237555A1

  公开（公告）日：2013-09-12

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开涉及一般可抑制AAK1（适配器相关激酶1）的化合物，包括这些化合物的组合物，以及抑制AAK1的方法。
• [EN] HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES<br/>[FR] PESTICIDES À BASE D'AZOLE BICYCLIQUE SUBSTITUÉ PAR HÉTÉROCYCLE
  申请人：DU PONT

  公开号：WO2016144351A1

  公开（公告）日：2016-09-15

  Disclosed are compounds of Formula (I), including all geometric and stereoisomers, N-oxides, and salts thereof, Formula (I) wherein Q is Formula (I) and A, R1, m, X1, X2, X3, X4, Y1, Y2 and Y3 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  揭示了式（I）的化合物，包括所有的立体异构体、N-氧化物和盐，式（I）中Q为式（I），A、R1、m、X1、X2、X3、X4、Y1、Y2和Y3如披露中所定义。还披露了含有式（I）化合物的组合物，以及控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与本发明的化合物或组合物的生物有效量接触。
• [EN] HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES<br/>[FR] PESTICIDES À BASE D'AZOLE BICYCLIQUE SUBSTITUÉ PAR UN HÉTÉROCYCLE
  申请人：DU PONT

  公开号：WO2015038503A1

  公开（公告）日：2015-03-19

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, and A, R1, m, X1, X2, X3, X4, Y1, Y2 and Y3 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  本文披露了Formula 1的化合物，包括所有几何和立体异构体、N-氧化物和盐，其中A、R1、m、X1、X2、X3、X4、Y1、Y2和Y3的定义如披露所述。同时披露了含有Formula 1化合物的组合物，以及用于控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与本发明的化合物或组合物的生物有效量接触。
• ARYL ETHER-BASE KINASE INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160222021A1

  公开（公告）日：2016-08-04

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开涉及能够抑制AAK1（适配器相关激酶1）的化合物、包含这些化合物的组合物以及抑制AAK1的方法。