3,6-dimethylpyrazine-2-thiol | 5788-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,6-dimethylpyrazine-2-thiol
• 英文别名: 3,6-dimethyl-1H-pyrazine-2-thione
• CAS: 5788-49-8
• 化学式: C₆H₈N₂S
• 分子量: 140.209
• InChiKey: ARBPVCYTFYHIPO-UHFFFAOYSA-N

物化性质

• 熔点：
  180-181 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 沸点：
  212.9±23.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)
• LogP：
  0.508 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,6-dimethylpyrazine-2-thiol 、 7-甲基苯并呋喃 、 乙酸酐 生成 2,5-dimethyl-3-acetylthio-pyrazine
  参考文献：
  名称：

  Flavoring agent

  摘要：

  化学式为##STR1##的噻吩硫化合物，其中X为乙烯基，R为氢或甲基基团；或者X为羰基基团，R为乙基基团或呋喃基团。

  公开号：

  US04138410A1
• 作为产物：
  描述：

  3,6-二甲基-1H-吡嗪-2-酮 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 3,6-dimethylpyrazine-2-thiol
  参考文献：
  名称：

  Effects of 3,6-Dimethylpyrazine-2-thiol on Reproductive and Accessory Reproductive Organs in Male Rats.

  摘要：

  The weights of prostate and seminal vesicle were decreased by treatment with 3, 6-dimethylpyrazine-2-thiol (3, 6-DMP-SH) but the weights of testes and the plasma testosterone levels were not changed. The recovery of the weight of prostate and seminal vesicles of testosterone-treated orchidectomized rats were inhibited by treatment with 3, 6-DMP-SH. Direct injection of 3, 6-DMP-SH into accessory reproductive organs also induced the decrease in the weight of relevant organs. Administration of oxendrone or chlormazinone along with 3, 6-DMP-SH decreased the weights of accessory reproductive organs more than administration of only one substance. In vitro uptake of testosterone into prostate and seminal vesicle were blocked by the presence of 3, 6-DMP-SH. These results suggest that 3, 6-DMP-SH directly inhibited testosterone uptake into the accessory reproductive organs.

  DOI：

  10.1248/bpb.19.360

文献信息

• Furfurylthioacetone
  申请人：Firmenich & Cie

  公开号：US03952024A1

  公开（公告）日：1976-04-20

  The chemical compound furfurylthioacetone which is useful as a flavor additive for foodstuffs and beverages.

  化学化合物糠醛硫代丙酮，在食品和饮料中作为风味添加剂非常有用。
• 5-Methyl-furfuryl furfuryl ether
  申请人：Firmenich & Cie

  公开号：US03952026A1

  公开（公告）日：1976-04-20

  The compound 5-methyl-furfuryl furfuryl ether which is useful as a flavor additive for foodstuffs and beverages.

  这个化合物是5-甲基-呋喃基呋喃醚，可作为食品和饮料的味道添加剂。
• Flavoring with pyrazine derivatives
  申请人：Firmenich SA

  公开号：US04303689A1

  公开（公告）日：1981-12-01

  The subject matter relates to flavoring with a composition of matter consisting essentially of a pyrazine derivative having the following formula: ##STR1## wherein (a) R.sup.1 is a methyl group and R.sup.2 is either an alkyl group having from 2 to 6 carbon atoms which can be branched at the chain end when said chain has 3 or 4 carbon atoms, or a vinyl, a thienyl-2 or a pyrryl-1 group; or (b) R.sup.1 is an ethyl group and R.sup.2 is an ethyl or a vinyl group.

  本主题涉及使用由基本上由具有以下公式的吡嗪衍生物组成的物质进行调味：##STR1##其中（a）R.sup.1是甲基基团，R.sup.2是具有2到6个碳原子的烷基基团，当该链具有3或4个碳原子时，可以在链末端分支，或者是乙烯基、噻吩-2或吡咯-1基团; 或（b）R.sup.1是乙基基团，R.sup.2是乙基或乙烯基团。
• Pyridine sulfur flavoring agents
  申请人：Firmenich & Cie

  公开号：US04085109A1

  公开（公告）日：1978-04-18

  Pyridine sulfur compounds of the formula: ##STR1## wherein R is acetyl when n is 0; R is ethyl or acetyl when n is 1; and R is furfuryl when n is 2; which are useful as flavor additives for foodstuffs and beverages.

  该配方的吡啶硫化合物：##STR1## 其中当n为0时，R为乙酰基；当n为1时，R为乙基或乙酰基；当n为2时，R为呋喃基。这些化合物可作为食品和饮料的香料添加剂。
• Ethyl or acetyl derivatives of 2-pyridylmethanethiol
  申请人：Firmenich & Cie

  公开号：US04126618A1

  公开（公告）日：1978-11-21

  Pyridine sulfur compounds of the formula: ##STR1## wherein R is ethyl or acetyl which are useful as flavor additives for foodstuffs and beverages.

  式子为：##STR1## 其中R为乙酰或乙酸乙酯，可用作食品和饮料的香味添加剂。