C-[1-(3,4,5-trimethoxy-phenyl)-cyclopentyl]-methylamine | 850263-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: C-[1-(3,4,5-trimethoxy-phenyl)-cyclopentyl]-methylamine
• 英文别名: 1-(3,4,5-Trimethoxyphenyl)cyclopentanemethanamine；[1-(3,4,5-trimethoxyphenyl)cyclopentyl]methanamine
• CAS: 850263-81-9
• 化学式: C₁₅H₂₃NO₃
• 分子量: 265.353
• InChiKey: LXXUJEQOKUNKOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-苯并呋喃-2-羰酰氯 、 C-[1-(3,4,5-trimethoxy-phenyl)-cyclopentyl]-methylamine 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 以11.7%的产率得到benzofuran-2-carboxylic acid [1-(3,4,5-trimethoxy-phenyl)-cyclopentylmethyl]-amide
  参考文献：
  名称：

  [EN] MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS
  [FR] MODULATEURS DES TRANSPORTEURS DES CASSETTES DE FIXATION DE L'ATP

  摘要：

  公开号：

  WO2005035514A3

文献信息

• Modulators of ATP-binding cassette transporters
  申请人：Hadida Ruah S. Sara

  公开号：US20050148648A1

  公开（公告）日：2005-07-07

  The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R B , n, B, R C , R D , R E , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

  本发明提供了公式I的化合物，作为ABC转运蛋白活性调节剂或其药学上可接受的盐，其中RB、n、B、RC、RD、RE、A和Z如下所述。本发明还提供了与公式I相关的制药组合物、方法和试剂盒，用于作为调节剂，并用于治疗与ABC转运蛋白相关的疾病和疾病状况。
• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Hadida-Ruah Sara S.

  公开号：US20120035179A1

  公开（公告）日：2012-02-09

  The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R B , n, B, R C , R D , R E , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

  本发明提供了I式化合物，其作为ABC转运蛋白活性调节剂或其药学上可接受的盐有用，其中RB、n、B、RC、RD、RE、A和Z通常在以下类别和子类别中描述。本发明还提供了与I式相关的制药组合物、方法和工具包，有用于调节剂和用于治疗与ABC转运蛋白相关的疾病和疾病条件。
• Modulators of ATP-Binding Cassette Transporters
  申请人：Hadida Ruah Sara S.

  公开号：US20100125090A1

  公开（公告）日：2010-05-20

  The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R B , n, B, R C , R D , R E , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

  本发明提供了公式I的化合物，它们可用作ABC转运蛋白活性调节剂或其药学上可接受的盐，其中RB、n、B、RC、RD、RE、A和Z通常和在下面的类和亚类中描述。本发明还提供了与公式I相关的制药组合物、方法和工具包，可用于作为调节剂，并用于治疗与ABC转运蛋白相关的疾病和疾病状况。
• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1680411A2

  公开（公告）日：2006-07-19
• [EN] MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS<br/>[FR] MODULATEURS DES TRANSPORTEURS DES CASSETTES DE FIXATION DE L'ATP
  申请人：VERTEX PHARMA

  公开号：WO2005035514A2

  公开（公告）日：2005-04-21

  The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.