N11474 | 3719-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N11474
• 英文别名: 3,4-Dimethoxy-phenylacetic acid <6-methyl-benzothiazol-2-ylamide>；2-(3,4-dimethoxy-phenyl)-N-(6-methoxy-benzothiazol-2-yl)-acetamide；2-(3,4-dimethoxyphenyl)-N-(6-methoxy-1,3-benzothiazol-2-yl)acetamide
• CAS: 3719-08-2
• 化学式: C₁₈H₁₈N₂O₄S
• mdl: MFCD02862197
• 分子量: 358.418
• InChiKey: MOEMIZXXDRAQAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N11474 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 苯 为溶剂， 反应 72.0h， 生成 (3,4-dimethoxy-phenethyl)-(6-methoxy-benzothiazol-2-yl)-amine
  参考文献：
  名称：

  Some N-Substituted Dimethoxyphenylacetamides and Dimethoxyphenylethylamines

  摘要：

  DOI：

  10.1021/jm00329a054
• 作为产物：
  描述：

  2-氨基-6-甲氧基苯并噻唑 、 3,4-二甲氧基苯基乙酸乙酯 生成 N11474
  参考文献：
  名称：

  Some N-Substituted Dimethoxyphenylacetamides and Dimethoxyphenylethylamines

  摘要：

  DOI：

  10.1021/jm00329a054

文献信息

• COMPOSITION FOR PROMOTING CARDIAC DIFFERENTIATION OF PLURIPOTENT STEM CELL COMPRISING EGFR INHIBITOR
  申请人：KYOTO UNIVERSITY

  公开号：US20160002600A1

  公开（公告）日：2016-01-07

  The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an EGFR inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an EGFR inhibitor and a method for inducing cardiac differentiation of a pluripotent stem cell comprising culturing the pluripotent stem cell in a medium containing an EGFR inhibitor.

  本发明提供了一种含有EGFR抑制剂的促进多能干细胞心脏分化的组合物。本发明还提供了一种含有EGFR抑制剂的促进心脏分化的试剂盒，以及一种诱导多能干细胞心脏分化的方法，包括在含有EGFR抑制剂的培养基中培养多能干细胞。
• Composition for promoting cardiac differentiation of pluripotent stem cell comprising EGFR inhibitor
  申请人：Kyoto University

  公开号：US10196609B2

  公开（公告）日：2019-02-05

  The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an EGFR inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an EGFR inhibitor and a method for inducing cardiac differentiation of a pluripotent stem cell comprising culturing the pluripotent stem cell in a medium containing an EGFR inhibitor.

  本发明提供了一种含有表皮生长因子受体抑制剂的促进多能干细胞心脏分化的组合物。本发明还提供了一种含有表皮生长因子受体抑制剂的促进心脏分化的试剂盒，以及一种诱导多能干细胞心脏分化的方法，该方法包括在含有表皮生长因子受体抑制剂的培养基中培养多能干细胞。
• Method for inducing cardiac differentiation of pluripotent stem cell with low-molecular compounds
  申请人：KYOTO UNIVERSITY

  公开号：US10233426B2

  公开（公告）日：2019-03-19

  The present invention provides a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing a WNT signaling activator and a PKC activator and (2) culturing the cell after the step (1) in a medium containing a WNT signaling inhibitor, a Src inhibitor, and an EGFR inhibitor.

  本发明提供了一种诱导多能干细胞心脏分化的方法，该方法包括以下步骤：（1）在含有WNT信号激活剂和PKC激活剂的培养基中培养多能干细胞；（2）在步骤（1）之后，在含有WNT信号抑制剂、Src抑制剂和表皮生长因子受体抑制剂的培养基中培养细胞。
• METHOD FOR PROMOTING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO CARDIAC MUSCLE CELLS
  申请人：Kyoto University

  公开号：US20130183753A1

  公开（公告）日：2013-07-18

  The present invention relates to a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells, and a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells and a method for preparing cardiac muscle cells.
• Method for Inducing Cardiac Differentiation of Pluripotent Stem Cell with Low-Molecular Compounds
  申请人：KYOTO UNIVERSITY

  公开号：US20170152485A1

  公开（公告）日：2017-06-01

  The present invention provides a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing a WNT signaling activator and a PCK activator and (2) culturing the cell after the step (1) in a medium containing a WNT signaling inhibitor, a Src inhibitor, and an EGFR inhibitor.