2-十八烷基壳聚糖-1-醇 | 14536-62-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-十八烷基壳聚糖-1-醇
• 英文名称: octadecylicosanol
• 英文别名: 2-Octadecylicosan-1-ol
• CAS: 14536-62-0
• 化学式: C₃₈H₇₈O
• 分子量: 551.037
• InChiKey: IKVOILQLHOZSKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.9
• 重原子数：
  39
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  prop-2-enyl (2S,4S,5S,6R)-5-acetamido-4-acetyloxy-2-fluoro-6-[(1R,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate 、 2-十八烷基壳聚糖-1-醇 生成 prop-2-enyl (2R,4S,5S,6R)-5-acetamido-4-acetyloxy-2-(2-octadecylicosoxy)-6-[(1R,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate
  参考文献：
  名称：

  KUNZ, HORST;WALDMANN, HERBERT;KLINKHAMMER, UWE, HELV. CHIM. ACTA, 71,(1988) N, C. 1868-1874

  摘要：

  DOI：

文献信息

• FLUORENE COMPOUND
  申请人：Ajinomoto Co., Inc.

  公开号：US20140046022A1

  公开（公告）日：2014-02-13

  Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.

  具有芴骨架的特定化合物在广泛的应用和稳定性方面表现出优越性，可作为液相合成氨基酸和/或肽的保护试剂。
• The Allyl Ester as Carboxy-Protecting Group in the Stereoselective Construction of Neuraminic-Acid Glycosides
  作者：Horst Kunz、Herbert Waldmann、Uwe Klinkhammer

  DOI：10.1002/hlca.19880710804

  日期：1988.12.14

  The application of the allyl-ester moiety as protecting principle for the carboxy group of N-acetylneuraminic acid is described. Peracetylated allyl neuraminate 2 is synthesized by reacting the caesium salt of the acid 1 with allyl bromide. Treatment of 2 with HCl in AcCl or with HF/pyridine gives the corresponding 2-chloro or 2-fluoro derivatives 3 and 4, respectively (Scheme 1). In the presence of

  描述了烯丙基酯部分作为N-乙酰神经氨酸的羧基的保护原理的应用。全乙酰烯丙基neuraminate 2是由酸的铯盐反应而合成1用烯丙基溴。用HCl在AcCl中或用HF /吡啶处理2，分别得到相应的2-氯或2-氟衍生物3和4（方案1）。在Ag 2 CO 3的存在下，2-氯碳水化合物3与二-O-异亚丙基保护的半乳糖5反应得到2-6个连接的二糖，其中α-D-端基异构体6a占主导地位（α-D/β-D= 6：1；方案2）。用BF 3 ·Et 2 O活化2-氟衍生物4时，优先形成β-D-异头物6b（α-D/β-D＝ 1∶5）。在进一步用长链醇进行的4的糖基化中，仅形成β-D-异头物（参见10和11；方案4）。烯丙基酯部分可以通过Pd（0）催化的烯丙基转移到吗啉作为亲核试剂选择性地和定量地从神经氨酸衍生物和神经氨酸二糖中去除（参见方案5））。
• SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS
  申请人：Taft David

  公开号：US20110009571A1

  公开（公告）日：2011-01-13

  Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
• US8524259B2
  申请人：——

  公开号：US8524259B2

  公开（公告）日：2013-09-03
• US9029504B2
  申请人：——

  公开号：US9029504B2

  公开（公告）日：2015-05-12