9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-2,7-divinylfluorene | 1229706-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-2,7-divinylfluorene
• 英文别名: 2,7-bis(ethenyl)-9,9-bis[2-[2-(2-methoxyethoxy)ethoxy]ethyl]fluorene
• CAS: 1229706-40-4
• 化学式: C₃₁H₄₂O₆
• 分子量: 510.671
• InChiKey: WGBBXDNWRKXXAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  37
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对甲苯磺酸三缩乙二醇单甲醚酯 在 bis-triphenylphosphine-palladium(II) chloride 、 2,6-二叔丁基苯酚 、 四丁基溴化铵 、 potassium hydroxide 、 lithium bromide 作用下， 以 水 、 二甲基亚砜 、 丙酮 、 甲苯 为溶剂， 反应 7.0h， 生成 9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)ethyl)-2,7-divinylfluorene
  参考文献：
  名称：

  季铵盐功能化的球型共轭聚合物纳米粒子及 其抗菌应用

  摘要：

  本发明公开了一种季铵盐功能化的球型共轭聚合物纳米粒子及其抗菌应用，该纳米粒子是以疏水性共轭聚合物为内核，季铵盐功能团分子通过疏水作用在其表面形成外壳，最终得到球型的共轭聚合物纳米粒子，其中疏水性共轭聚合物的结构式为季铵盐功能团分子的结构式为本发明共轭聚合物纳米粒子在避光条件下，无需光源或其他能量即可实现广谱高效抗菌，其抗菌率远远高于相同浓度功能团分子的抗菌率，并不易产生耐药性，为未来抗菌纳米材料的开发提供了新的思路。

  公开号：

  CN108815529B

文献信息

• Methods And Compositions For Cellular Imaging And Cancer Cell Detection Using Light Harvesting Conjugated Polymer-Biomolecular Conjugates
  申请人：NATIONAL UNIVERSITY OF SINGAPORE

  公开号：US20130189727A1

  公开（公告）日：2013-07-25

  The invention is a compound represented by any one of Structural Formulas (I)-(IV), or a salt thereof, wherein the values and alternative values for the variables are as defined in the Detailed Description of the Invention. Methods using a compound of Structural Formula (I)-(IV), or a salt thereof, are also presented.

  本发明涉及一种由结构式（I）-（IV）中的任何一种化合物或其盐所代表的化合物，其中变量的值和可替代值如本发明详细说明书所定义。本发明还提供了使用结构式（I）-（IV）中的化合物或其盐的方法。
• Multicolor Conjugate Polyelectrolyte/Peptide Complexes as Self-Assembled Nanoparticles for Receptor-Targeted Cellular Imaging
  作者：Kan-Yi Pu、Kai Li、Bin Liu

  DOI：10.1021/cm102788b

  日期：2010.12.28

  An anionic conjugated polyelectrolyte (CPE, P1) with energy donor acceptor architecture is synthesized and assembled with an Arg-Gly-Asp (RGD) terminated peptide to form fluorescent nanoparticles (FNs) with targeting capability. Complexation between oppositely charged P1 and the peptide at different molar ratio results in FNs with different size and fluorescence varying from sky-blue to orange-red because of aggregation-enhanced fluorescence resonance energy transfer (FRET). At the P1/peptide molar ratio of 8:0.9, the FNs exhibit bright orange-red fluorescence with a quantum yield of 16% and a large Stokes shift of 195 nm. In addition, these FNs also possess low cytotoxicity and good photostability. By virtue of the specific binding between RGD and integrin receptors, the P1/peptide FNs serve as an effective probe for receptor-targeted fluorescence imaging of HT29 cancer cells. This study thus provides a facile and generic strategy to prepare a new generation of multicolor polymeric FNs with native targeting capability and controllable properties for biological applications.
• [EN] METHODS AND COMPOSITIONS FOR CELLULAR IMAGING AND CANCER CELL DETECTION USING LIGHT HARVESTING CONJUGATED POLYMER- BIOMOLECULAR CONJUGATES<br/>[FR] PROCÉDÉS ET COMPOSITIONS DESTINÉS À L'IMAGERIE CELLULAIRE ET À LA DÉTECTION DE CELLULES CANCÉREUSES À L'AIDE DE CONJUGUÉS BIOMOLÉCULAIRES-POLYMÈRES CONJUGUÉS COLLECTEURS DE LUMIÈRE
  申请人：UNIV SINGAPORE

  公开号：WO2012002911A1

  公开（公告）日：2012-01-05

  The present invention relates to conjugated polyelectrolyte (CPE) or oligoelectrolyte (COE) compounds represented by general structural formulae (I) -(IV), or a salt thereof and methods of using these compounds to detect targets in samples. In particular, the methods include: (1) exposing a sample to a compound of structural formula (I), (II) or (IV) or a salt thereof, allowing the compound to bind to a target and detecting a signal produced by the compound; (2) functionalizing a solid support with a ligand, incubating the sample with a charged CPE or COE and detecting the fluorescence of the solid support and thereby detecting the target or (3) functionalizing a surface of a solid support with a charged ligand, thereby creating a charge on the surface of the solid support; incubating the ligand-functionalized solid support with a sample, whereupon binding of the target, the charge on the surface of the solid support switches; incubating the sample with CPE or COE that has a complementary charge to the charge of the target-bound surface; and detecting the fluorescence of the solid support and thereby detecting the target. The compounds of the present invention possess high photoluminescence quantum yields in biological media, low cytotoxicity, and excellent environmental stability and photostability and can be used in biosensor and bioimaging applications.
• 季铵盐功能化的球型共轭聚合物纳米粒子及 其抗菌应用
  申请人：陕西师范大学

  公开号：CN108815529B

  公开（公告）日：2021-07-09

  本发明公开了一种季铵盐功能化的球型共轭聚合物纳米粒子及其抗菌应用，该纳米粒子是以疏水性共轭聚合物为内核，季铵盐功能团分子通过疏水作用在其表面形成外壳，最终得到球型的共轭聚合物纳米粒子，其中疏水性共轭聚合物的结构式为季铵盐功能团分子的结构式为本发明共轭聚合物纳米粒子在避光条件下，无需光源或其他能量即可实现广谱高效抗菌，其抗菌率远远高于相同浓度功能团分子的抗菌率，并不易产生耐药性，为未来抗菌纳米材料的开发提供了新的思路。