(2S)-2-aminopentanedioic acid;(2S)-2-amino-3-phenylpropanoic acid | 26655-91-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-aminopentanedioic acid;(2S)-2-amino-3-phenylpropanoic acid
• CAS: 26655-91-4
• 化学式: C14H20N2O6
• 分子量: 312.32
• InChiKey: IWLPNOCXQJLPAX-YYTBSQRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  164
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Process for production of physiologically active peptide containing cysteine residue
  申请人：SUNTORY LIMITED

  公开号：EP0281418A2

  公开（公告）日：1988-09-07

  A process for the production of a physiologically active peptide (a target peptide) containing cysteine residue, comprising the steps of: (1) culturing Escherichia coli transformed with a plasmid capable of expressing a fusion protein under control of a promoter of E. coli origin or a promoter of a phage origin, wherein the fusion protein is represented by the following formula:       A - L - B wherein B represents a target peptide containing cysteine residue; A represents a partner polypeptide consisting of 90 to 220 amino acid residue but not containing cysteine residue; and L represents a linker amino acid residue positioned between C-terminal of the partner polypeptide and N-terminal of the target peptide wherein the same amino acid as the linker amino acid is not present in the target peptide, and the linker amino acid is selected so that the peptide bond between the C-terminal of the linker amino acid and the N-terminal of the target peptide is claimed by a protease or the linker amino acid is selectively degraded by a chemical substance; (2) disrupting the cultured cells and obtain­ing an insoluble fraction containing the fusion protein; (3) solubilizing the fusion protein with a solubilizing agent, and treating the solubilized fusion protein with the protease or the chemical substance to liberate the target peptide, and isolating the target peptide.

  一种生产含有半胱氨酸残基的生理活性肽（目标肽）的工艺，包括以下步骤 (1) 培养用质粒转化的大肠杆菌，该质粒能在大肠杆菌源性启动子或噬菌体源性启动子的控制下表达融合蛋白，其中融合蛋白由下式表示： A - L - B 其中 B 代表含有半胱氨酸残基的目标肽；A 代表由 90 至 220 个氨基酸残基组成但不含半胱氨酸残基的伙伴多肽；L 代表位于伙伴多肽的 C 末端和目标肽的 N 末端之间的连接氨基酸残基，其中与连接氨基酸相同的氨基酸不存在于目标肽中，连接氨基酸的选择是为了使连接氨基酸的 C 末端和目标肽的 N 末端之间的肽键被蛋白酶破坏或连接氨基酸被化学物质选择性降解； (2) 破坏培养细胞并获得含有融合蛋白的不溶部分； (3) 用增溶剂增溶融合蛋白，用蛋白酶或化学物质处理增溶的融合蛋白以释放目的肽，并分离目的肽。
• Anti-inflammatory peptides
  申请人：Salpep Biotechnology, Inc.

  公开号：EP2072524A2

  公开（公告）日：2009-06-24

  Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1 - X2 - X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid; 2-amino-heptanoic acid; 2-amino-octanoic acid; cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine; X2 is an acidic amino acid; and X3 is an aliphatic amino acid; or of a peptide of the formula: X4 - X5 wherein X4 is an aromatic or aliphatic amino acid; and X5 is an acidic amino acid.

  提供了抑制哺乳动物炎症反应的方法和药物组合物。这些方法包括向哺乳动物施用有效量的式肽： 其中 X1 选自以下组成的组 2-氨基己酸；2-氨基庚酸；2-氨基辛酸；环己基取代的 2-氨基乙酸、2-氨基丙酸或 2-氨基丁酸和蛋氨酸；X2 是酸性氨基酸；和 X3 是脂肪族氨基酸；或式中的肽：其中 X4 是芳香族或脂肪族氨基酸；X5 是酸性氨基酸。
• Phosphorus-containing polymers for optical signal transducers
  申请人：——

  公开号：US20020114604A1

  公开（公告）日：2002-08-22

  The invention relates to a phosphorus-containing polymer for coating dielectric materials, to processes for its preparation and to its use, as well as to an optical signal transducer having a coating of the polymer and to its use.

  本发明涉及一种用于介电材料涂层的含磷聚合物、其制备工艺和用途，还涉及一种具有该聚合物涂层的光信号换能器及其用途。
• Splice variant isoforms of human calcium channel CACNA1B
  申请人：——

  公开号：US20040081988A1

  公开（公告）日：2004-04-29

  The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of calcium channel &agr; 1B subunit (CACNA 1 B). The polynucleotide sequence of CACNA 1 Bsv1 is provided by SEQ ID NO 1 and the polynucleotide sequence of CACNA 1 Bsv2 is provided by SEQ ID NO 3. The amino acid sequence for CACNA 1 Bsv1 is provided by SEQ ID NO 2 and the amino acid sequence for CACNA 1 Bsv1 is provided by SEQ ID NO 4. The present invention also provides methods for using CACNAlBsv1 and CACNA 1 Bsv2 polynucleotides and the respective proteins to screen for compounds that bind to CACNA 1 Bsv1 and CACNA 1 Bsv2.

  本发明的特点是用核酸和多肽编码钙通道 &agr； 1B 亚基（CACNA 1 B).CACNA 1 B 的多核苷酸序列为 1 Bsv1 的多核苷酸序列由 SEQ ID NO 1 提供，而 CACNA 1 1 Bsv2 的多核苷酸序列由 SEQ ID NO 3 提供。 1 Bsv1 的氨基酸序列由 SEQ ID NO 2 提供，CACNA 1 1 Bsv1 的氨基酸序列由 SEQ ID NO 4 提供。本发明还提供了使用 CACNAlBsv1 和 CACNA 1 Bsv2 多核苷酸和各自的蛋白质来筛选与 CACNA 1 Bsv1 和 CACNA 1 Bsv2 结合的化合物。
• Process and compositions for preparing phenylalanine
  申请人：RHONE-POULENC CHIMIE

  公开号：EP0132999B1

  公开（公告）日：1992-01-15