2-{acetoxy-[3-(2-chloro-phenyl)-isoxazol-5-yl]-methyl}acrylic acid methyl ester | 601520-85-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{acetoxy-[3-(2-chloro-phenyl)-isoxazol-5-yl]-methyl}acrylic acid methyl ester
• CAS: 601520-85-8
• 化学式: C₁₆H₁₄ClNO₅
• 分子量: 335.744
• InChiKey: LBFCZWKJBRFVEX-UHFFFAOYSA-N

物化性质

• 沸点：
  488.9±45.0 °C(Predicted)
• 密度：
  1.288±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  2-{acetoxy-[3-(2-chloro-phenyl)-isoxazol-5-yl]-methyl}acrylic acid methyl ester 在 三乙烯二胺 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 0.5h， 生成 3-[3-(2-Chloro-phenyl)-isoxazol-5-yl]-2-(4-methyl-piperazin-1-ylmethyl)-propionic acid methyl ester
  参考文献：
  名称：

  Baylis–Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

  摘要：

  The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted -5-isoxazolecarb-aldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.02.023
• 作为产物：
  描述：

  3-O-chlorophenylisoxazole-5-carbaldehyde 在 吡啶 、 三乙烯二胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.83h， 生成 2-{acetoxy-[3-(2-chloro-phenyl)-isoxazol-5-yl]-methyl}acrylic acid methyl ester
  参考文献：
  名称：

  Baylis–Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

  摘要：

  The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted -5-isoxazolecarb-aldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.02.023

文献信息

• Isoxazole-based derivatives from Baylis–Hillman chemistry: assessment of preliminary hypolipidemic activity
  作者：A Patra、S Batra、A.P Bhaduri、A Khanna、R Chander、M Dikshit

  DOI：10.1016/s0968-0896(03)00105-6

  日期：2003.5

  The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Persistent splenomegaly in an adult female with homozygous sickle cell anemia
  作者：Sompal Singh、Deepak Kumar Singh、Ruchika Gupta、Sonu Nigam、Tejinder Singh

  DOI：10.1080/01650420500328365

  日期：2006.2

  Sickle cell anemia (SCA) is associated with repeated episodes of erythrostasis in the spleen, which lead to thrombosis and infarction of the spleen resulting in "autosplenectomy" which is usually complete by 8 years of age.We present a case of a 22-year-old female who presented with complaints of fever, bone pain and joint swelling. On examination she had pallor, icterus and moderate splenomegaly. Her hemoglobin was 7.5g/dl. Peripheral smear showed many sickled red cells. Slide test for sickling was positive with 2% sodium metabisulphite. Hemoglobin electrophoresis revealed a single band in the hemoglobin S, D, and G region. No band was seen in the HbA & HbA(2) region. HbF level was 0%. USG showed an enlarged spleen with few defined hypoechoeic lesion.We present this case because of rarity of association of homozygous SCA with splenomegaly in this age group, the confusion that echogenic lesions in spleen can create and to emphasize the risk of sequestration crises, which remains in such cases.