2,2'-imino-di-octanoic acid | 306314-24-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2'-imino-di-octanoic acid
• 英文别名: Di-n-heptyl-amin-α.α'-dicarbonsaeure；α.α'-Imino-dicaprylsaeure；2,2'-Imino-di-octansaeure；2-(1-Carboxyheptylamino)octanoic acid
• CAS: 306314-24-9
• 化学式: C₁₆H₃₁NO₄
• 分子量: 301.426
• InChiKey: MIIYTTIHHGVMKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  盐酸 、 2,2'-imino-di-octanoic acid 生成 庚醛 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Erlenmeyer; Sigel, Justus Liebigs Annalen der Chemie, 1875, vol. 177, p. 103

  摘要：

  DOI：
• 作为产物：
  描述：

  1-amino-heptan-1-ol 在 盐酸 作用下， 生成 2,2'-imino-di-octanoic acid
  参考文献：
  名称：

  Erlenmeyer; Sigel, Justus Liebigs Annalen der Chemie, 1875, vol. 177, p. 103

  摘要：

  DOI：

文献信息

• ASYMMETRIC IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
  申请人：Arcturus Therapeutics, Inc.

  公开号：US20150239926A1

  公开（公告）日：2015-08-27

  What is described is a compound of formula I wherein R 1 consists of a linear or branched alkyl consisting of 1-18 carbons, an alkenyl or alkynyl consisting of 2 to 12 carbons, or a cholesteryl; R 2 consists of a linear or branched alkyl or an alkenyl consisting of 1 to 18 carbons; L 1 consists of a linear alkyl consisting of 5 to 9 carbons or, when R 1 consists of a cholesteryl then L 1 consists of a linear alkylene or alkenyl consisting of 3 to 4 carbons; X 1 consists of —O—(CO)— or —(CO)—O—; X 2 consists of S or O; L 2 consists of a bond or a linear alkylene of 1 to 6 carbons; R 3 consists of a linear or branched alkylene with 1 to 6 carbons; and R 4 and R 5 are the same or different, each consisting of a linear or branched alkyl of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

  描述的是一种I式化合物，其中R1由1-18个碳原子的线性或支链烷基、2-12个碳原子的烯基或炔基，或胆固醇基组成；R2由1-18个碳原子的线性或支链烷基或烯基组成；L1由5-9个碳原子的线性烷基组成，或者当R1由胆固醇基组成时，L1由3-4个碳原子的线性烷基或烯基组成；X1由—O—(CO)—或—(CO)—O—组成；X2由S或O组成；L2由键或1-6个碳原子的线性烷基组成；R3由1-6个碳原子的线性或支链烷基组成；R4和R5相同或不同，均由1-6个碳原子的线性或支链烷基组成；或其药学上可接受的盐。
• LIPID PARTICLES WITH ASYMMETRIC CATIONIC LIPIDS FOR RNA DELIVERY
  申请人：Arcturus Therapeutics, Inc.

  公开号：US20160244761A1

  公开（公告）日：2016-08-25

  What is described is a lipid particle comprising the compound of formula I wherein R 1 consists of alkyl, alkenyl, alkynyl, or cholesteryl; R 2 consists of alkyl or alkenyl; L 1 consists of alkyl, alkylene or alkenyl; X 1 consists of —O—(CO)— or —(CO)—O—; X 2 consists of S or O; L 2 consists of a bond or alkylene; R 3 consists of alkylene; and R 4 and R 5 are the same or different, each consisting of alkyl; or a pharmaceutical preparation thereof.

  描述的是一种脂质颗粒，包括化合物I的公式，其中R1由烷基，烯基，炔基或胆固醇基组成；R2由烷基或烯基组成；L1由烷基，烷基烯基或烯基组成；X1由—O—（CO）—或—（CO）—O—组成；X2由S或O组成；L2由键或烷基烷基组成；R3由烷基烷基组成；R4和R5相同或不同，均由烷基组成；或其制备的药物制剂。
• Method of synthesis of an ionizable cationic lipid
  申请人：Arcturus Therapeutics, Inc.

  公开号：US10781169B2

  公开（公告）日：2020-09-22

  Disclosed herein is a lipid composition comprising a compound having the formula IA, or a pharmaceutically acceptable salt thereof, wherein R3 is a linear or branched alkylene of 1-6 carbons; R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1-6 carbons; and L3 is a bond or an alkane of 1-6 carbons.

  本文公开了一种脂质组合物，它包含具有式 IA 的化合物或其药学上可接受的盐、 其中 R3 是 1-6 个碳原子的直链或支链亚烷基 R4 和 R5 相同或不同，各自为氢或 1-6 碳的直链或支链烷基；以及 L3 是键或 1-6 个碳原子的烷烃。
• IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
  申请人：Arcturus Therapeutics, Inc.

  公开号：US20170144967A1

  公开（公告）日：2017-05-25

  What is described is a compound wherein R 1 and R 2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbons; L 1 and L 2 are the same or different, each a linear alkyl having 3 to 18 carbons; X 1 and X 3 are —CO—O—; X 3 is S or O; L 3 is a lower alkyl; R 3 is a lower alkyl; and R 4 and R 5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
• METHOD OF SYNTHESIS OF AN IONIZABLE CATIONIC LIPID
  申请人：Arcturus Therapeutics, Inc.

  公开号：US20180208555A1

  公开（公告）日：2018-07-26

  What is described is a method of synthesis of the compound of formula 1A, or a salt thereof, wherein R 3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R 4 and R 5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L 3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.