dimethyl 2-pentene-1,5-dicarboxylate | 177780-24-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dimethyl 2-pentene-1,5-dicarboxylate
• 英文别名: dimethyl (E)-hept-3-enedioate
• CAS: 177780-24-4
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: IOIQPNHUWAGYII-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PYRAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES<br/>[FR] COMPOSES DE PYRAZOLE EN TANT QU'ANTAGONSITES DES RECEPTEURS DE L'INTEGRINE
  申请人：PHARMACIA CORP

  公开号：WO2004058761A1

  公开（公告）日：2004-07-15

  The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the αVβ3 and/or the α Vβ5 integrin without significantly inhibiting the α Vβ6 integrin.

  本发明涉及包含式(I)化合物的制药组合物，以及选择性地抑制或拮抗αVβ3和/或αVβ5整合素的方法，而不显著抑制αVβ6整合素。
• Pyrazole compounds as integrin receptor antagonists derivatives
  申请人：Penning D. Thomas

  公开号：US20050004200A1

  公开（公告）日：2005-01-06

  The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the α V β 3 and/or the α V β 5 integrin without significantly inhibiting the α V β 6 integrin.

  本发明涉及一类由公式I表示的化合物或其药学上可接受的盐，包括由公式I的化合物组成的药物组合物，以及选择性地抑制或拮抗αVβ3和/或αVβ5整合素而不显著抑制αVβ6整合素的方法。
• Heteroarylalkanoic acids as integrin receptor antagonists derivatives
  申请人：Boys L. Mark

  公开号：US20050043344A1

  公开（公告）日：2005-02-24

  The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the α V β 3 and/or the α V β 5 integrin without significantly inhibiting the α V β 6 integrin.

  本发明涉及包含式I的化合物或其药学上可接受的盐的制药组合物，以及选择性地抑制或拮抗αVβ3和/或αVβ5整合素的方法，而不显著抑制αVβ6整合素。
• Process for preparing unsaturated dicarboxylic acid diesters
  申请人：IDEMITSU PETROCHEMICAL CO. LTD.

  公开号：EP0457197A1

  公开（公告）日：1991-11-21

  The present invention discloses a process for efficiently preparing an unsaturated dicarboxylic acid diester, which comprises reacting a conjugated diene, carbon monoxide, an alcohol and oxygen in the presence of a catalyst comprising (a) a platinum metal, a salt thereof or a complex compound of a platinum metal, (b) at least one salt of metal selected from copper, iron and manganese and (c) at least one compound selected from (1) an alkali metal compound or an alkaline earth metal compound, (2) a rare earth metal compound, (3) a metal compound of the groups IIIA, IVA, IVB, VA, VB or VIA, and (4) a metal carbonyl complex. According to the present invention, an unsaturated dicarboxylic acid diester useful as an intermediate material in chemical industry can be efficiently prepared with use of no dehydrating agent.

  本发明公开了一种高效制备不饱和二羧酸二酯的工艺，该工艺包括在催化剂存在下使共轭二烯、一氧化碳、醇和氧反应，催化剂包括 (a) 铂金属、其盐或铂金属的络合物、 (b) 至少一种选自铜、铁和锰的金属盐，以及 (c) 至少一种化合物，选自 (1) 碱金属化合物或碱土金属化合物，(2) 稀土金属化合物，(3) IIIA、IVA、IVB、VA、VB 或 VIA 族金属化合物，和 (4) 金属羰基络合物。 根据本发明，无需使用脱水剂，即可高效制备用作化学工业中间材料的不饱和二羧酸二酯。
• PYRAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES
  申请人：Pharmacia Corporation

  公开号：EP1572691A1

  公开（公告）日：2005-09-14