1-(4-pyridyl)-2-methylaminoethanol | 36695-59-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(4-pyridyl)-2-methylaminoethanol
• 英文别名: 2-Methylamino-1-(4)-pyridyl-ethanol；2-methylamino-1-pyridin-4-yl-ethanol；2-Methylamino-1-pyridine-4-yl-ethanol；rac-2-(methylamino)-1-pyridin-4-ylethanol；2-(Methylamino)-1-(pyridin-4-yl)ethan-1-ol；2-(methylamino)-1-pyridin-4-ylethanol
• CAS: 36695-59-7
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: HIJIFZKLOPYMOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-二氯苯乙酸 、 1-(4-pyridyl)-2-methylaminoethanol 在 N-甲基吗啉 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 1-(4-pyridyl)-2-(N-(2-(3,4-dichlorophenyl)acetyl)-N-methylamino)ethanol
  参考文献：
  名称：

  靶向人羊毛甾醇14α-脱甲基酶（CYP51）的新型胆固醇生物合成抑制剂。

  摘要：

  合成了新型胆固醇生物合成抑制剂，一组吡啶基乙醇（苯乙基）胺衍生物。在人肝癌HepG2细胞中的甾醇谱分析表明该化合物靶向人羊毛甾醇14α-脱甲基酶（CYP51）。与过量表达的人CYP51结合的结构-活性关系研究表明，吡啶与唑类类似物在血红素结合口袋中结合。

  DOI：

  10.1016/j.bmc.2007.10.001
• 作为产物：
  描述：

  2-bromo-1-pyridin-4-ylethanol;hydrobromide 、 甲胺 以 甲醇 为溶剂， 生成 1-(4-pyridyl)-2-methylaminoethanol
  参考文献：
  名称：

  2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

  摘要：

  A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.102

文献信息

• Heterocyclic compound having oxime group
  申请人：Yoshida Ichiro

  公开号：US20050227959A1

  公开（公告）日：2005-10-13

  The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to the present invention, disclosed is the compound represented by the General Formula (I) [where R 1 and R 2 independently represent a C 1-6 alkyl group and the like that may have a hydrogen atom or a substituent; R 3 represents a C 1-6 alkyl group and the like that may have a substituent; R 4 and R 5 independent represents a hydrogen atom or a C 1-6 alkyl group and the like that may have a substituent; R 6 represents a hydrogen atom and the like; W represents —SO 2 — and the like; and X represents a sulphur atom and the like.]or a salt thereof, or a hydrate thereof.

  本发明提供了一种对STAT6激活具有优异抑制活性且对过敏疾病有效的化合物及其药物组合物。根据本发明，公开了由通式（I）表示的化合物[其中R1和R2独立地表示可能具有氢原子或取代基等的C1-6烷基基团；R3表示可能具有取代基的C1-6烷基基团等；R4和R5独立地表示可能具有取代基的氢原子或C1-6烷基基团等；R6表示氢原子等；W表示—SO2—等；X表示硫原子等]或其盐或水合物。
• [EN] HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES D'HETEROARYL-ETHANOLAMINE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2004022567A1

  公开（公告）日：2004-03-18

  The present invention provides a compound of formula (I), which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种化合物(I)的公式，其作为抗病毒剂特别是抗疱疹病毒家族的药剂。
• Pyrimidine derivatives as ALK-5 inhibitors
  申请人：Novartis AG

  公开号：EP1878733A1

  公开（公告）日：2008-01-16

  Compounds of formula I in free or salt or solvate form, where T1, T2, K, Ra and Rb have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  公式I中的化合物以自由形式、盐或溶剂形式存在，其中T1、T2、K、Ra和Rb的含义如规范中所示，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。还描述了含有这些化合物的药物组合物以及制备这些化合物的过程。
• AZETIDINE POLYSUBSTITUTED COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF
  申请人：Bernardelli Patrick

  公开号：US20110152236A1

  公开（公告）日：2011-06-23

  The invention relates to compounds of the formula (I) where: R is a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group; R1 is a hydrogen atom; R2 is a heteroaromatic group or a heteroaromatic(C 1 -C 4 )alkyl group, said groups being optionally substituted; R3 and R4 represent independently from each other an optionally substituted phenyl group; Y is a hydrogen atom, a halogen, a cyano, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkoxy group, a halo(C 1 -C 6 )alkoxy group or a (C 1 -C 6 )alkylS(O) p group; and p is 0 to 2. Said compounds can be in the form — of a base or a salt for addition to an acid. The invention also relates to a method for preparing same and to the therapeutic application thereof.

  该发明涉及化合物的结构式（I），其中：R是（C1-C6）烷基基团，卤代（C1-C6）烷基基团；R1是氢原子；R2是杂环芳基团或杂环芳基（C1-C4）烷基基团，这些基团可以选择性地被取代；R3和R4分别独立地表示一个可以选择性取代的苯基团；Y是氢原子、卤素、氰基、（C1-C6）烷基基团、卤代（C1-C6）烷基基团、（C1-C6）烷氧基、卤代（C1-C6）烷氧基或（C1-C6）烷基S（O）p基团；p为0至2。所述化合物可以以盐的形式存在，用于与酸发生加成反应。该发明还涉及制备该化合物的方法及其治疗应用。
• [EN] NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX DERIVES D'AMINES PYRIDYLETHANOL (PHENYLETHYL) UTILES COMME INHIBITEURS DE LA BIOSYNTHESE DU CHOLESTEROL, LEURS PROCEDES DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：LEK PHARMACEUTICALS

  公开号：WO2004007456A1

  公开（公告）日：2004-01-22

  The novel derivatives of pyridylethanol (phenylethyl) amines of formula I are described wherein n is an integer from 1 to 4, R1 is a hydrogen atom, hydroxyl group or lower C1-6 alkoxy group R2 is a hydrogen atom or a straight or branched lower C1-6 alkyl group X, is hydrogen, fluorine, chlorine, bromine, hydroxyl group, trifluoromethyl group, 3,4-di-CI,2,4-di-CI or lower C1-6 alkoxy group, the enantiomers, diastereoisomers or racemates thereof or the physiologically acceptable acid addition salts thereof which are ligands of sigma receptors for inhibiting cholesterol biosynthesis and are thus appropriate for the treatment of hypercholesterolemia and hyperlipemia in humans. The greatest lowering of cholesterol was observed by 1-(d-pyridyl)-2-(N-(2-(3,4-dicholorophenyl)ethyl-N-propylamino)ethanol in the form of dihydrobromide salt (signature BK-35. 2HBr).

  描述了式I的吡啶乙醇（苯乙基）胺的新颖衍生物，其中n是1到4的整数，R1是氢原子、羟基或较低的C1-6烷氧基团，R2是氢原子或直链或支链的较低的C1-6烷基团，X是氢、氟、氯、溴、羟基、三氟甲基、3,4-二氯、2,4-二氯或较低的C1-6烷氧基团，其对映体、二对映异构体或混合物或其生理上可接受的酸盐是sigma受体的配体，用于抑制胆固醇生物合成，因此适用于治疗人类高胆固醇血症和高脂血症。1-(d-吡啶基)-2-(N-(2-(3,4-二氯苯基)乙基-N-丙基氨基)乙醇在二氢溴化物盐形式中观察到了最大的胆固醇降低作用（签名BK-35.2HBr）。