Boc-Ala-Phe-Trp-OCH3 | 1201848-49-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Ala-Phe-Trp-OCH3
• CAS: 1201848-49-8
• 化学式: C₂₉H₃₆N₄O₆
• 分子量: 536.628
• InChiKey: MDWGRXZSYXIWTH-NWVWQQAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.01
• 重原子数：
  39.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  138.62
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Boc-Ala-Phe-Trp-OCH3 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat

  摘要：

  We have synthesized a series of new beta-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that beta-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat. Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2011.03.029

文献信息

• Rh(III)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks
  作者：Shulei Hu、Yu Zhang、Xiong Xie、Luhan Li、Kaixian Chen、Hong Liu、Jiang Wang

  DOI：10.1016/j.cclet.2023.109408

  日期：2024.8

  Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability, increased potency and selectivity. Here, we present a rapid synthesis method for constructing Trp(C7)-alkene()-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells, through C-H alkenylation and macrolactamization. This report addresses critical challenges associated with the installation

  杂环支撑的环肽已被证明具有增强的代谢稳定性、增强的效力和选择性。在这里，我们提出了一种快速合成方法，通过 CH 烯基化和大环内酰胺化构建具有有效抗癌细胞增殖活性的 Trp(C7)-alkene()-交联环肽。该报告解决了与导向基团 -Piv 的安装和去除、烯烃的构型选择性以及分子内环化相关的关键挑战。值得注意的是，该方法表现出温和的反应条件、无痕去除导向基团和高构型选择性。