4-溴-3-硝基苯甲酮 | 62100-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-溴-3-硝基苯甲酮
• 英文名称: 4'-Brom-3-nitro-benzophenon
• 英文别名: 4'-bromo-3-nitro-benzophenone；(4-Brom-phenyl)-(3-nitro-phenyl)-keton；(4-bromo-phenyl)-(3-nitro-phenyl)-methanone；4-Bromo-3'-nitrobenzophenone；(4-bromophenyl)-(3-nitrophenyl)methanone
• CAS: 62100-13-4
• 化学式: C₁₃H₈BrNO₃
• 分子量: 306.115
• InChiKey: LMPHOJDMACTBKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  4-溴-3-硝基苯甲酮 在 硫酸 、 硝酸 作用下， 以 1,1-二氯乙烷 为溶剂， 以72%的产率得到3,3'-dinitro-4-bromo benzophenone
  参考文献：
  名称：

  Kinase Inhibitors

  摘要：

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调节、调控和/或抑制异常细胞增殖。

  公开号：

  US20070032478A1
• 作为产物：
  描述：

  溴苯 在 aluminum (III) chloride 、 N,N-二甲基甲酰胺 作用下， 反应 4.42h， 以88%的产率得到4-溴-3-硝基苯甲酮
  参考文献：
  名称：

  Kinase Inhibitors

  摘要：

  本发明涉及有机分子，能够调节酪氨酸激酶信号传导，以调节、调控和/或抑制异常细胞增殖。

  公开号：

  US20070032478A1

文献信息

• [EN] ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF<br/>[FR] ANTICORPS ANTI-VISTA HUMAINS ET UTILISATION ASSOCIÉE
  申请人：IMMUNEXT INC

  公开号：WO2021216913A1

  公开（公告）日：2021-10-28

  The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.

  本发明提供了抗VISTA抗体药物偶联物，可用于针对免疫细胞（例如，髓系细胞）的靶向递送抗炎剂，例如类固醇。本发明还提供了在治疗炎症和/或自身免疫状况以及/或减轻抗炎剂（如类固醇）的毒性中使用抗VISTA抗体药物偶联物的方法。
• Phenylethynyl amine
  申请人：The United States of America as represented by the Administrator of the

  公开号：US05599993A1

  公开（公告）日：1997-02-04

  Four phenylethynyl amine compounds--3 and 4-aminophenoxy-4'-phenylethynylbenzophenone, and 3 and 4-amino-4'-phenylethynylbenzophenone--were readily prepared and were used to endcap imide oligomers. Phenylethynyl-terminated amide acid oligomers and phenylethynyl-terminated imide oligomers with various molecular weights and compositions were prepared and characterized. These oligomers were cured at 300.degree. C. to 400.degree. C. to provide crosslinked polyimides with excellent solvent resistance, high strength and modulus and good high temperature properties. Adhesive panels, composites, films and moldings from these phenylethynyl terminated imide oligomers gave excellent mechanical performance.

  四种苯乙炔胺化合物——3和4-氨基苯氧基-4'-苯乙炔基苯并酮，以及3和4-氨基-4'-苯乙炔基苯并酮——很容易制备，并用于封端酰亚胺寡聚物。制备和表征了具有不同分子量和组成的苯乙炔基终止的酰胺酸寡聚物和苯乙炔基终止的酰亚胺寡聚物。这些寡聚物在300℃至400℃下固化，形成耐溶剂性、高强度和模量以及良好高温性能的交联聚酰亚胺。使用这些苯乙炔基终止的酰亚胺寡聚物制备的粘合板、复合材料、薄膜和模塑品表现出优异的机械性能。
• Phenylethynyl terminated imide oligomers
  申请人：Ther United States of America as represented by the Administrator of the

  公开号：US05412066A1

  公开（公告）日：1995-05-02

  Four phenylethynyl amine compounds--3 and 4-aminophenoxy-4'-phenylethynylbenzophenone, and 3 and 4-amino-4'-phenylethynylbenzophenone--were readily prepared and were used to endcap imide oligomers. Phenylethynyl-terminated amide acid oligomers and phenylethynyl-terminated imide oligomers with various molecular weights and compositions were prepared and characterized. These oligomers were cured at 300.degree. C. to 400.degree. C. to provide crosslinked polyimides with excellent solvent resistance, high strength and modulus and good high temperature properties. Adhesive panels, composites, films and moldings from these phenylethynyl terminated imide oligomers gave excellent mechanical performance.

  四种苯乙炔胺化合物——3-氨基苯氧基-4'-苯乙炔基苯并酮和4-氨基苯氧基-4'-苯乙炔基苯并酮，以及3-氨基-4'-苯乙炔基苯并酮和4-氨基-4'-苯乙炔基苯并酮——可以轻松制备，并用于封端酰亚胺低聚物。制备和表征了具有不同分子量和组成的苯乙炔基末端酰胺酸低聚物和苯乙炔基末端酰亚胺低聚物。这些低聚物在300°C至400°C下固化，形成耐溶剂、高强度和模量以及良好高温性能的交联聚酰亚胺。使用这些苯乙炔基末端酰亚胺低聚物制备的粘接板、复合材料、薄膜和模塑品具有出色的机械性能。
• Kinase inhibitors
  申请人：Allergan, Inc.

  公开号：US07749530B2

  公开（公告）日：2010-07-06

  The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

  本发明涉及药物输送系统，包括眼内植入物，其中包括有机分子，能够调节酪氨酸激酶信号转导，以调节、调节和/或抑制异常细胞增殖，与聚合物结合使用，该聚合物用于控制、修改、调节和/或减缓治疗成分释放到所放置的眼部环境中。
• WO2008/22013
  申请人：——

  公开号：——

  公开（公告）日：——