1-Benzotriazol-1-yl-butan-1-ol | 111507-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-Benzotriazol-1-yl-butan-1-ol
• 英文别名: 1-(Benzotriazol-1-yl)butan-1-ol
• CAS: 111507-80-3
• 化学式: C₁₀H₁₃N₃O
• 分子量: 191.233
• InChiKey: HUKDKRKZKNOOMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  T406石油添加剂 、 正丁醛 以100%的产率得到1-Benzotriazol-1-yl-butan-1-ol
  参考文献：
  名称：

  Katritzky, Alan R.; Rachwal, Stanislaw; Rachwal, Bogumila, Journal of the Chemical Society. Perkin transactions I, 1987, p. 791 - 798

  摘要：

  DOI：

文献信息

• KATRITZKY A. R.; RACHWAL S.; RACHWAL B., J. CHEM. SOC. PERKIN TRANS.,(1987) N 4, 791-797
  作者：KATRITZKY A. R.、 RACHWAL S.、 RACHWAL B.

  DOI：——

  日期：——
• MACROCYCLIC COMPOUND AND USE THEREOF
  申请人：Scohia Pharma, Inc.

  公开号：EP3890738A1

  公开（公告）日：2021-10-13
• [EN] MACROCYCLIC COMPOUND AND USE THEREOF<br/>[FR] COMPOSÉ MACROCYCLIQUE ET SON UTILISATION
  申请人：SCOHIA PHARMA INC

  公开号：WO2020116660A1

  公开（公告）日：2020-06-11

  A compound represented by the following formula (I): wherein each symbol in the formula is as described herein or a salt thereof has an NRF2 activating activity, and is expected to be useful as a preventive or therapeutic agent for diseases associated with oxidative stress, in particular, hepatic disease (for example, non-alcoholic steatohepatitis (NASH)), cardiovascular disease (for example, heart failure or pulmonary arterial hypertension), lung disease (for example, chronic obstructive pulmonary disease (COPD)), kidney disease (for example, chronic kidney disease (CKD) or acute kidney injury (AKI)), central nervous system disease (for example, Parkinson's disease), mitochondrial disease (for example, Friedreich motor ataxia, mitochondrial myopathy), inflammatory disease (for example, multiple sclerosis (MS), inflammatory bowel disease (IBD)), sickle cell disease, cancer, or the like.