(R)-methyl 2-((tert-butoxycarbonyl)(5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)acetate | 1307231-16-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-methyl 2-((tert-butoxycarbonyl)(5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)acetate
• 英文别名: methyl 2-[[(1R)-5-[5-(3-cyano-4-propan-2-yloxyphenyl)-1,2,4-oxadiazol-3-yl]-1,2,3,4-tetrahydronaphthalen-1-yl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetate
• CAS: 1307231-16-8
• 化学式: C₃₀H₃₄N₄O₆
• 分子量: 546.623
• InChiKey: MVTYQLFUYSBUQE-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  128
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS
  申请人：RECEPTOS, INC.

  公开号：US20130196966A1

  公开（公告）日：2013-08-01

  Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

  提供了选择性调节鞘氨醇1磷酸受体的化合物，包括调节S1P受体亚型1的化合物。提供了这些化合物的手性合成方法。在医学上需要调节鞘氨醇1磷酸受体的疾病、不良状态和障碍的治疗或预防方法以及制备包括创新化合物的创新组合物的方法。
• US9394264B2
  申请人：——

  公开号：US9394264B2

  公开（公告）日：2016-07-19