(7-methoxy-3,7-dimethyl-2,4-octadien-1-yl)triphenylphosphonium bromide | 130681-69-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (7-methoxy-3,7-dimethyl-2,4-octadien-1-yl)triphenylphosphonium bromide
• 英文别名: (7-Methoxy-3,7-dimethyl-2,4-octadienyl)triphenylphosphonium bromide；((E,E)-7-methoxy-3,7-dimethyl-octa-2,4-dienyl)-triphenyl-phosphonium; bromide；[(2E,4E)-7-methoxy-3,7-dimethylocta-2,4-dienyl]-triphenylphosphanium;bromide
• CAS: 130681-69-5
• 化学式: Br*C₂₉H₃₄OP
• 分子量: 509.466
• InChiKey: JWTYOPMDGVDJES-YOLDXNEBSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (7-methoxy-3,7-dimethyl-2,4-octadien-1-yl)triphenylphosphonium bromide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 (14'-13C)spheroidene
  参考文献：
  名称：

  Gebhart, R.; Hoef, K. van der; Lefeber, A. W. M., Recueil des Travaux Chimiques des Pays-Bas, 1990, vol. 109, # 6, p. 378 - 387

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲氧基-6-甲基庚烷-2-酮 在 N-溴代丁二酰亚胺(NBS) 、 lithium aluminium tetrahydride 、 sodium hydride 、 碳酸氢钠 、 N,N-二乙基苯胺 、 calcium oxide 作用下， 以 甲醇 、 四氯化碳 、 乙醚 为溶剂， 反应 5.0h， 生成 (7-methoxy-3,7-dimethyl-2,4-octadien-1-yl)triphenylphosphonium bromide
  参考文献：
  名称：

  Gebhart, R.; Hoef, K. van der; Lefeber, A. W. M., Recueil des Travaux Chimiques des Pays-Bas, 1990, vol. 109, # 6, p. 378 - 387

  摘要：

  DOI：

文献信息

• Carotenoids and related compounds. Part XVI. Structural and synthetic studies on spirilloxanthin, chloroxanthin, spheroidene, and spheroidenone
  作者：M. S. Barber、L. M. Jackman、P. S. Manchand、B. C. L. Weedon

  DOI：10.1039/j39660002166

  日期：——

  The structure of spirilloxanthin (rhodoviolascin) was unambiguously determined by degradative and nuclear magnetic resonance spectral studies. Similar studies indicated the structures of chloroxanthin, spheroidene (“Pigment Y”), and spheroidenone (“Pigment R”); these structures have been confirmed by total syntheses.

  通过降解和核磁共振谱研究清楚地确定了螺菌黄质（视紫红霉素）的结构。相似的研究表明，氯黄嘌呤，椭球体（“ Y颜料”）和椭球酮（“ R颜料”）的结构；这些结构已通过总合成得到证实。
• Gebhard, R.; Dijk, J. T. M. van; Boza, M. V. T. J., Recueil des Travaux Chimiques des Pays-Bas, 1991, vol. 110, # 7-8, p. 332 - 341
  作者：Gebhard, R.、Dijk, J. T. M. van、Boza, M. V. T. J.、Hoef, K. van der、Lugtenburg, J.

  DOI：——

  日期：——
• Gebhard, R.; Dijk, J. T. M. van; Ouwerkerk, E. van, Recueil des Travaux Chimiques des Pays-Bas, 1991, vol. 110, # 11, p. 459 - 469
  作者：Gebhard, R.、Dijk, J. T. M. van、Ouwerkerk, E. van、Boza, M. V. T. J.、Lugtenburg, J.

  DOI：——

  日期：——
• COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA
  申请人：ezCol B.V.

  公开号：EP3897677A1

  公开（公告）日：2021-10-27
• [EN] COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA<br/>[FR] COMPOSITION À UTILISER DANS UNE MÉTHODE VISANT À ABAISSER LE TAUX PLASMATIQUE DE CHOLESTÉROL LBD
  申请人：EZCOL B V

  公开号：WO2020130813A1

  公开（公告）日：2020-06-25

  The present invention relates to a (pharmaceutical) composition comprising geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10, for use in a method for the lowering of LDL-cholesterol in subjects in need thereof. Furthermore, the invention relates to a foodstuff comprising a food supplement, wherein the food supplement has cholesterol-lowering properties and comprises compounds geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10. For the pharmaceutical composition and the composition and the food supplement the proviso is that the (pharmaceutical) composition is not, and the compounds are not provided as, a petroleum ether extract of Rhodospirillum rubrum obtainable by extraction of Rhodospirillum rubrum cells with a mixture of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride, wherein the extract is obtained by extraction for between 10 minutes and 48 hours at between 8°C and 37°C, while mixing the cells with the mixture, and wherein the Rhodospirillum rubrum cells are extracted with the mixture in a volume ratio of between 10:1 and 1:10 of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride. Furthermore, the (pharmaceutical) composition and compounds are not comprising or provided as whole R.rubrum cells or as a membrane fraction of R.rubrum.