3-(4-Bromo-2-methoxyphenyl)propanal | 1261674-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-Bromo-2-methoxyphenyl)propanal
• CAS: 1261674-90-1
• 化学式: C₁₀H₁₁BrO₂
• 分子量: 243.1
• InChiKey: KOSNITVJQQQCET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORYT
  申请人：Janssen Pharmaceutica NV

  公开号：EP3790865A1

  公开（公告）日：2021-03-17
• [EN] PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORYT<br/>[FR] PYRAZOLES SUBSTITUÉS PAR PHÉNYLE UTILISÉS EN TANT QUE MODULATEURS DE RORYT
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2019243999A1

  公开（公告）日：2019-12-26

  The present invention comprises compounds of Formula (I). wherein: R1, R3, R4, R5, R6, R7, R8, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-y-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORĻγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).