(2S)-N-[1-[2-[2-(difluoromethyl)benzoimidazol-1-yl]-6-morpholin-4-yl-pyrimidin-4-yl]-4-piperidyl]piperidine-2-carboxamide | 1013327-00-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-N-[1-[2-[2-(difluoromethyl)benzoimidazol-1-yl]-6-morpholin-4-yl-pyrimidin-4-yl]-4-piperidyl]piperidine-2-carboxamide
• 英文别名: (2S)-N-[1-[2-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-ylpyrimidin-4-yl]piperidin-4-yl]piperidine-2-carboxamide
• CAS: 1013327-00-8
• 化学式: C₂₇H₃₄F₂N₈O₂
• 分子量: 540.616
• InChiKey: YTKWVABOQAALBZ-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• 2-BENZIMIDAZOLYL-6-MORPHOLINO-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：Butterworth Sam

  公开号：US20100022534A1

  公开（公告）日：2010-01-28

  The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R 1 , R 2, q, R 3 , r, R 4 , s, t, X 1 and Q 1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in a method for producing an anti-proliferative effect in a warm blooded animal such as man.

  本发明涉及式（I）的嘧啶衍生物，其中p，R1，R2，q，R3，r，R4，s，t，X1和Q1中的每一个都具有描述中定义的任何含义；它们的制备方法，含有它们的制药组合物以及它们在制造抗增殖效应的方法中的用途，该方法适用于温血动物，例如人类。
• 2 -BENZIMIDAZOLYL- 6 -MORPHOLINO-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：AstraZeneca AB

  公开号：EP2069330A1

  公开（公告）日：2009-06-17
• [EN] 2 -BENZIMIDAZOLYL- 6 -MORPHOLINO-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS<br/>[FR] DÉRIVÉS DE PYRIMIDINE 2 -BENZIMIDAZOLYL- 6 -MORPHOLINO-4- (AZÉTIDINE, PYRROLIDINE, PIPÉRIDINE OU AZÉPINE) UTILES COMME INHIBITEURS DE PI3K ET MTOR DANS LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：ASTRAZENECA AB

  公开号：WO2008032028A1

  公开（公告）日：2008-03-20

  [EN] The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R¹, R^2, q, R³, r, R⁴, s, t, X¹ and Q¹ have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in a method for producing an anti-proliferative effect in a warm blooded animal such as man.
  [FR] L'invention concerne des dérivés de l'pyrimidine de formule (I) dans laquelle chacun de p, R¹, R^2, q, R³, r, R⁴, s, t, X¹ et Q¹ ont les notations définies dans le descriptif. L'invention concerne également des procédés de préparation de ces dérivés, des compositions pharmaceutiques les contenant et leur utilisation dans un procédé visant à générer un effet prolifératif chez un animal à sang chaud tel que l'homme.