4-(2-diethylamino-ethoxy)-isophthalic acid bis-(2-diethylamino-ethyl ester) | 103042-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-diethylamino-ethoxy)-isophthalic acid bis-(2-diethylamino-ethyl ester)
• 英文别名: 4-(2-Diaethylamino-aethoxy)-isophthalsaeure-bis-(2-diaethylamino-aethylester)
• CAS: 103042-97-3
• 化学式: C₂₆H₄₅N₃O₅
• 分子量: 479.66
• InChiKey: PYEXJLKRPAZTKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  34.0
• 可旋转键数：
  18.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  71.55
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  4-羟基间苯二甲酸 、 N,N-二乙基氯乙胺 在 sodium hydroxide 、 丙酮 作用下， 生成 4-(2-diethylamino-ethoxy)-isophthalic acid bis-(2-diethylamino-ethyl ester)
  参考文献：
  名称：

  Organisation of the amygdalo-thalamic pathways in rats

  摘要：

  This study examines the organisation of the pathways from the amygdala to the thalamus. Amygdaloid nuclei (medial, central, basolateral and olfactory groups) of Sprague-Dawley rats were injected with biotinylated dextran using stereotaxic coordinates and their brains were then aldehyde-fixed and processed using standard methods. We have three major findings. First, the amygdala has a distinct set of projections to particular nuclei of the thalamus. The thalamic nuclei with the heaviest amygdaloid terminations include the zona incerta, the mediodorsal and the midline nuclei. Second, nuclei of different amygdaloid groups project to the thalamus in slightly different patterns. For example, some groups of nuclei project to the thalamic reticular nucleus (e.g. medial, olfactory) whilst others do not (e.g. central, basolateral). Thus, there is a certain amount of heterogeneity within the amygdaloid projections to the thalamus. Third, when we compare our results on the amygdalothalamic pathways to the many previous descriptions of the thalamo-amygdaloid pathways, we note that they are largely out of register. In other words, some of the thalamic nuclei that project to a given group of amygdaloid nuclei do not necessarily receive a projection back from that same amygdaloid nucleus. Hence, there is no substrate for a strong feed-back relationship between the thalamus and the amygdala, as there has been shown for other centres of the brain (e.g. between the thalamus and neocortex).

  DOI：

  10.1007/pl00008229