5-tert-butyl 1-ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate | 761443-68-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 5-tert-butyl 1-ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate
• 英文别名: 3-[4-(morpholin-4-yl)benzamido]-1-ethoxycarbonyl-5-t-butyloxycarbonyl-4,6-dihydropyrrolo[3,4-c]pyrazole；5-O-tert-butyl 1-O-ethyl 3-[(4-morpholin-4-ylbenzoyl)amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate
• CAS: 761443-68-9
• 化学式: C₂₄H₃₁N₅O₆
• 分子量: 485.54
• InChiKey: IXLMERWCIPIJFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
  申请人：Fancelli Daniele

  公开号：US20060276471A1

  公开（公告）日：2006-12-07

  Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本发明公开了式(I)的吡咯并[3,4-c]吡唑衍生物及其药学上可接受的盐的制备方法和包含它们的制药组合物；本发明中的化合物可能在治疗与蛋白激酶活性失调有关的疾病，如癌症中有用。
• PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：EP1644376B1

  公开（公告）日：2010-09-08
• US7582628B2
  申请人：——

  公开号：US7582628B2

  公开（公告）日：2009-09-01
• [EN] PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DERIVES DU PYRROLO[3,4-C]PYRAZOLE ACTIFS COMME INHIBITEURS DES KINASES
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2005005427A1

  公开（公告）日：2005-01-20

  [EN] Pyrrolo[3,4-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
  [FR] L'invention porte: sur des dérivés du pyrrolo[3,4-c]pyrazole de formule (I) et leurs sels pharmacocompatibles, tels que définis dans la spécification; sur leur procédé de préparation; et sur des préparations pharmaceutiques les comprenant. Lesdits composés peuvent servir en thérapie au traitement de maladies, associées à un dérèglement de l'activité des protéines kinases, telles que le cancer.