4,4-dimethyl-cycloheptanecarboxylic acid amide | 99175-64-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4,4-dimethyl-cycloheptanecarboxylic acid amide
• 英文别名: 4,4-Dimethyl-cycloheptancarbonsaeure-amid；4,4-Dimethylcycloheptane-1-carboxamide
• CAS: 99175-64-1
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: JRMNZRVJIVTWGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 4,4-dimethyl-cycloheptanecarboxylic acid amide
  参考文献：
  名称：

  对来自 LIBOCEDRUS FORMOSANA, FLORIN 木材的两种特征挥发性酸之一的 Shonanic 酸组成的研究。一、湘南酸的分离及其一般性质

  摘要：

  (1) 据报道，在台湾 Libocedrus、Florin 或“湘南木”的木材的挥发性部分中存在一种未知的酸。(2) Shonanic acid 是一种不饱和的一元酸，具有分子式为 C10H14O2 的单环结构，熔点 40-41°。它的酰胺在 116-117° 熔化，苯胺在 111-112° 熔化。(3) 湘南酸在催化还原时吸收四个氢原子可以转化为四氢湘酸，而它只吸收两个原子的溴，当用钠和乙醇还原时形成不饱和酸，即。得到二氢脂肪酸 (C10H16O2)。这些实验事实，再加上湘南酸的分子折射表现出显着的提升，得出的结论是其分子中存在共轭双键。(4) 虽然四氢芴酰胺在144°熔化，但证明该酸与二氢-α-樟脑酸（C10H18O2，酰胺熔点144°）有很大不同。(5)湘南酸异构化为异湘酸b...

  DOI：

  10.1246/bcsj.11.759

文献信息

• GLP-1 receptor modulators
  申请人：Celgene International II SÀRL

  公开号：US10034886B2

  公开（公告）日：2018-07-31

  Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “” represents either or both the R and S form of the compound): where A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined herein.

  本研究提供了调节胰高血糖素样肽 1（GLP-1）受体的化合物及其合成方法，以及治疗和/或预防使用方法。此类化合物可单独作为 GLP-1 受体的调节剂或增效剂，或与 GLP-1(7-36) 和 GLP-1(9-36)等增量肽一起使用，或与艾塞那肽和利拉鲁肽等肽类疗法一起使用，并具有以下一般结构（其中""代表化合物的 R 和 S 形式中的一种或两种）： 其中 A、B、C、Y1、Y2、Z、R1、R2、R3、R4、R5、W1、n、p 和 q 如本文所定义。
• Multiple attention systems in perceptual categorization
  作者：W. Todd Maddox、F. Gregory Ashby、Elliott M. Waldron

  DOI：10.3758/bf03194934

  日期：2002.4

  Five observers categorized inverted L-shaped stimuli according to the length of the horizontal line segment. A centrally located spatial cue preceded the stimulus on each trial. On 80% of the trials, the (relevant) horizontal line segment fell within the cued location, and on 20% of the trials the (irrelevant) vertical line segment fell within the cued location. The empirical results provide support for the hypothesis that perceptual attention can focus on the stimulus attribute inside the spatially cued location at the same time that decisional attention is focused on the (relevant) horizontal attribute-that is, the results suggest that perceptual and decisional attention can function independently during categorization. Decision bound models and extended generalized context models that assume separate perceptual and decisional attention systems were fitted to the data. Versions of the models that assume that the spatial cue affected perceptual attention were superior to versions that assume no effect on perceptual attention. These theoretical analyses support the functional independence hypothesis and suggest that formal theories of categorization should model the effects of perceptual and decisional attention separately.
• NOVEL GLP-1 RECEPTOR MODULATORS
  申请人：Celgene International II SÀRL

  公开号：US20180021346A1

  公开（公告）日：2018-01-25

  Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ ” represents either or both the R and S form of the compound): where A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.