(2S,4R)-methyl 4-fluoro-1-(4-fluorophenylsulfonyl)pyrrolidine-2-carboxylate | 1404560-51-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4R)-methyl 4-fluoro-1-(4-fluorophenylsulfonyl)pyrrolidine-2-carboxylate
• 英文别名: methyl (2S,4R)-4-fluoro-1-(4-fluorophenyl)sulfonylpyrrolidine-2-carboxylate
• CAS: 1404560-51-5
• 化学式: C₁₂H₁₃F₂NO₄S
• 分子量: 305.302
• InChiKey: GGVRRZFROLECRP-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• New Pharmaceutical Compounds
  申请人：Orion Corporation

  公开号：EP2520566A1

  公开（公告）日：2012-11-07

  Compounds of formula I, wherein A and R1-R7, are as defined in the claims, exhibit TRPA1 activity and are thus useful as TRPA1 modulators.

  式I中的化合物，其中A和R1-R7如索赔中所定义，表现出TRPA1活性，因此可用作TRPA1调节剂。
• [EN] PHENYL- SULFONYL DERIVATIVES AS MEDIATORS OF TRPA1 RECEPTOR ACTIVITY FOR THE TREATMENT OF PAIN<br/>[FR] DÉRIVÉS DE PHÉNYLSULFONYLE EN TANT QUE MÉDIATEURS DE L'ACTIVITÉ DE RÉCEPTEUR TRPA1 POUR LE TRAITEMENT DE LA DOULEUR
  申请人：ORION CORP

  公开号：WO2012152983A1

  公开（公告）日：2012-11-15

  Compounds of formula I, wherein A and R1-R7, are as defined in the claims, exhibit TRPA1 activity and useful as TRPA1 modulators.

  式I的化合物，其中A和R1-R7如索权中所定义，表现出TRPA1活性，并且作为TRPA1调节剂是有用的。
• SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
  申请人：Genentech, Inc.

  公开号：US20180118680A1

  公开（公告）日：2018-05-03

  The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.